TY - JOUR
T1 - Diabetes mellitus in a koala (Phascolarctos cinereus)
AU - Hemsley, Susan
AU - Govendir, Merran
AU - Canfield, Paul
AU - Connolly, Joanne
PY - 1998
Y1 - 1998
N2 - OBJECTIVE: To describe a case of diabetes mellitus in a koala (Phascolarctos cinereus). DESIGN: A case report with controls. PROCEDURES: We describe clinical and laboratory findings in a 6-year-old, free-living, female koala presented with traumatic injury and subsequently found to have polydipsia, hyperglycaemia and glucosuria. Over a 5 week period, serum biochemical analyses, haematological examinations, urinalyses, measurement of serum insulin and fructosamine concentrations, necropsy, histopathological examination of a range of tissues and immunohistochemical examination of the pancreas for insulin-containing cells were done. For reference purposes, serum insulin and fructosamine concentrations were determined in four and two healthy koalas, respectively, and three healthy koalas' pancreases were examined histologically and immunohistochemically. RESULTS: The koala had persistent hyperglycaemia, hyperlipidaemia, hyponatraemia, hypochloraemia and glucosuria. Serum insulin concentration of the diabetic koala was only marginally smaller than that of healthy koalas, but all concentrations were smaller than reference concentrations in dogs and people. Fructosamine concentration did not allow the diabetic koala to be distinguished from healthy koalas and concentrations of all koala analytes were greater than expected for healthy dogs and people. Histopathological examination revealed extensive degeneration of pancreatic islet cells and fatty infiltration of hepatocytes. Immunoperoxidase staining revealed decreased or absent insulin in the beta calls of the affected koala. CONCLUSION: Clinical signs, clinicopathological results and histopathological changes were consistent with diabetes mellitus. The pathogenesis of the condition could not be determined but may have been related to the administration of a parenteral corticosteroid preparation, the stress of capture or tissue damage and inflammation.
AB - OBJECTIVE: To describe a case of diabetes mellitus in a koala (Phascolarctos cinereus). DESIGN: A case report with controls. PROCEDURES: We describe clinical and laboratory findings in a 6-year-old, free-living, female koala presented with traumatic injury and subsequently found to have polydipsia, hyperglycaemia and glucosuria. Over a 5 week period, serum biochemical analyses, haematological examinations, urinalyses, measurement of serum insulin and fructosamine concentrations, necropsy, histopathological examination of a range of tissues and immunohistochemical examination of the pancreas for insulin-containing cells were done. For reference purposes, serum insulin and fructosamine concentrations were determined in four and two healthy koalas, respectively, and three healthy koalas' pancreases were examined histologically and immunohistochemically. RESULTS: The koala had persistent hyperglycaemia, hyperlipidaemia, hyponatraemia, hypochloraemia and glucosuria. Serum insulin concentration of the diabetic koala was only marginally smaller than that of healthy koalas, but all concentrations were smaller than reference concentrations in dogs and people. Fructosamine concentration did not allow the diabetic koala to be distinguished from healthy koalas and concentrations of all koala analytes were greater than expected for healthy dogs and people. Histopathological examination revealed extensive degeneration of pancreatic islet cells and fatty infiltration of hepatocytes. Immunoperoxidase staining revealed decreased or absent insulin in the beta calls of the affected koala. CONCLUSION: Clinical signs, clinicopathological results and histopathological changes were consistent with diabetes mellitus. The pathogenesis of the condition could not be determined but may have been related to the administration of a parenteral corticosteroid preparation, the stress of capture or tissue damage and inflammation.
KW - Koala
KW - Phascolarctos cinereus
KW - Diabetes mellitus
KW - immunohistochemistry
KW - pancreas
KW - hyperglycaemia
KW - glycosuria
U2 - 10.1111/j.1751-0813.1998.tb10130.x
DO - 10.1111/j.1751-0813.1998.tb10130.x
M3 - Article
SN - 0005-0423
VL - 76
SP - 203
EP - 208
JO - Australian Veterinary Journal
JF - Australian Veterinary Journal
IS - 3
ER -