TY - JOUR
T1 - Diabetes, oxidative stress and cardiovascular risk
AU - Butkowski, Eugene G.
AU - Brix, Lea M.
AU - Kiat, Hosen
AU - Al-Aubaidy, Hayder A.
AU - Jelinek, Herbert F.
N1 - Includes bibliographical references.
PY - 2016
Y1 - 2016
N2 - Type 2 Diabetes Mellitus (T2DM) and associated cardiovascular disease (CVD) is approaching global epidemic proportions with no signs of abatement. This current study examined correlations between inflammation and oxidative stress in (T2DM) and the Framingham CVD risk score. A cross sectional cohort of patients enrolling in the Diabetic Complications Research Initiative at Charles Sturt University was examined for diabetes status and divided into control, prediabetic, and a T2DM groups. The cohort was also divided with respect to Framingham CVD risk categories of low, moderate and high risk.Fasting lipid levels, blood glucose, glycated haemoglobin (HbA1c), interleukin 6, (IL-6), glutathione(GSH) and glutathione disulfide (GSSG) were measured. Body Mass Index (BMI), blood pressure andestimated glomerular filtration rate (eGFR) were included. Significant correlations in diabetes statusand CVD risk with GSH and IL-6 were observed. This study further supports previous data that inflammatory processes and oxidative stress are implicated in T2DM and CVD risk.
AB - Type 2 Diabetes Mellitus (T2DM) and associated cardiovascular disease (CVD) is approaching global epidemic proportions with no signs of abatement. This current study examined correlations between inflammation and oxidative stress in (T2DM) and the Framingham CVD risk score. A cross sectional cohort of patients enrolling in the Diabetic Complications Research Initiative at Charles Sturt University was examined for diabetes status and divided into control, prediabetic, and a T2DM groups. The cohort was also divided with respect to Framingham CVD risk categories of low, moderate and high risk.Fasting lipid levels, blood glucose, glycated haemoglobin (HbA1c), interleukin 6, (IL-6), glutathione(GSH) and glutathione disulfide (GSSG) were measured. Body Mass Index (BMI), blood pressure andestimated glomerular filtration rate (eGFR) were included. Significant correlations in diabetes statusand CVD risk with GSH and IL-6 were observed. This study further supports previous data that inflammatory processes and oxidative stress are implicated in T2DM and CVD risk.
KW - Type 2 Diabetes Mellitus
KW - Prediabetes
KW - Cardiovascular disease
KW - Oxidative stress
KW - Risk factors
KW - Body mass index
KW - Glutathione
KW - Glutathione disulfide
KW - Interleukin-6
UR - https://publons.com/journal/47149/journal-of-medicine-and-clinical-sciences/
M3 - Article
SN - 2315-6864
VL - 5
SP - 17
EP - 23
JO - Basic Research Journal of Medicine and Clinical Sciences
JF - Basic Research Journal of Medicine and Clinical Sciences
IS - 1
ER -
