Diagnosis, management, and future control of cholera

Fahima Chowdhury, Allen G Ross, Md Taufiqul Islam, Nigel A J McMillan, Firdausi Qadri

Research output: Contribution to journalReview articlepeer-review

4 Citations (Scopus)


SUMMARY Cholera, caused by Vibrio cholerae, persists in developing countries due to inadequate access to safe water, sanitation, and hygiene. There are approximately 4 million cases and 143,000 deaths each year due to cholera. The disease is transmitted fecally-orally via contaminated food or water. Severe dehydrating cholera can progress to hypovolemic shock due to the rapid loss of fluids and electrolytes, which requires a rapid infusion of intravenous (i.v.) fluids. The case fatality rate exceeds 50% without proper clinical management but can be less than 1% with prompt rehydration and antibiotics. Oral cholera vaccines (OCVs) serve as a major component of an integrated control package during outbreaks or within zones of endemicity. Water, sanitation, and hygiene (WaSH); health education; and prophylactic antibiotic treatment are additional components of the prevention and control of cholera. The World Health Organization (WHO) and the Global Task Force for Cholera Control (GTFCC) have set an ambitious goal of eliminating cholera by 2030 in high-risk areas.
Original languageEnglish
Article numbere0021121
Pages (from-to)1-23
Number of pages23
JournalClinical Microbiology Reviews
Issue number3
Early online date21 Jun 2022
Publication statusPublished - Sept 2022


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