Dietary lactoferrin supplementation to gilts during gestation and lactation improves pig production and immunity

Marefa Jahan, Susie Kracht, Yen Ho, Ziaul Haque, Birendra N. Bhattachatyya, Peter C. Wynn, Bing Wang

Research output: Contribution to journalArticle

4 Citations (Scopus)
9 Downloads (Pure)

Abstract

Lactoferrin (LF), a sialylated iron-binding glycoprotein, performs multiple beneficial functions including modulating immunity and improves neurodevelopment, health and growth performance. Maternal LF intervention for gilts (first parity sows) on the performance of gilts and their offspring remains unknown. In the current study gilts were fed with a commercial pig feed supplemented with 1g LF /day (treatment group) or 1g milk casein/day (control group) from day 1 post mating throughout pregnancy and lactation for about 135 days. The milk production and body weight gain was monitored. The immunoglobulin concentrations in the serum of gilts and piglets were measured using ELISA. Our study showed that maternal LF supplementation to the gilt (1) significantly increased milk production at different time points (day 1, 3, 7 and 19) of lactation compared to the control (p<0.001); (2) significantly increased body weight gain of their piglets during the first 19 days of life compared to the control group (p<0.05); (3) tended to increase pregnancy rate, litter size and birth weight, number of piglets born alive, and decrease the number of dead and intrauterine growth restriction (IUGR) piglets; (4) significantly increased the concentration of serum IgA in gilt and serum sIgA in piglet (p<0.05). In summary, maternal Lf intervention in gilts can improve milk production, pig production and serum IgA and sIgA levels, and therefore plays a key role in shaping the performance of their progeny.

Original languageEnglish
Article numbere0185817
JournalPLoS One
Volume12
Issue number10
DOIs
Publication statusPublished - 12 Oct 2017

Fingerprint

Lactoferrin
lactoferrin
Dietary Supplements
Lactation
gilts
Immunity
Milk
Swine
lactation
immunity
pregnancy
Pregnancy
piglets
Mothers
Serum
Immunoglobulin A
Weight Gain
Body Weight
milk production
Litter Size

Cite this

@article{2c96b91893a845c9a3d119d986436f47,
title = "Dietary lactoferrin supplementation to gilts during gestation and lactation improves pig production and immunity",
abstract = "Lactoferrin (LF), a sialylated iron-binding glycoprotein, performs multiple beneficial functions including modulating immunity and improves neurodevelopment, health and growth performance. Maternal LF intervention for gilts (first parity sows) on the performance of gilts and their offspring remains unknown. In the current study gilts were fed with a commercial pig feed supplemented with 1g LF /day (treatment group) or 1g milk casein/day (control group) from day 1 post mating throughout pregnancy and lactation for about 135 days. The milk production and body weight gain was monitored. The immunoglobulin concentrations in the serum of gilts and piglets were measured using ELISA. Our study showed that maternal LF supplementation to the gilt (1) significantly increased milk production at different time points (day 1, 3, 7 and 19) of lactation compared to the control (p<0.001); (2) significantly increased body weight gain of their piglets during the first 19 days of life compared to the control group (p<0.05); (3) tended to increase pregnancy rate, litter size and birth weight, number of piglets born alive, and decrease the number of dead and intrauterine growth restriction (IUGR) piglets; (4) significantly increased the concentration of serum IgA in gilt and serum sIgA in piglet (p<0.05). In summary, maternal Lf intervention in gilts can improve milk production, pig production and serum IgA and sIgA levels, and therefore plays a key role in shaping the performance of their progeny.",
author = "Marefa Jahan and Susie Kracht and Yen Ho and Ziaul Haque and Bhattachatyya, {Birendra N.} and Wynn, {Peter C.} and Bing Wang",
year = "2017",
month = "10",
day = "12",
doi = "10.1371/journal.pone.0185817",
language = "English",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science (PLoS)",
number = "10",

}

Dietary lactoferrin supplementation to gilts during gestation and lactation improves pig production and immunity. / Jahan, Marefa; Kracht, Susie; Ho, Yen; Haque, Ziaul; Bhattachatyya, Birendra N.; Wynn, Peter C.; Wang, Bing.

In: PLoS One, Vol. 12, No. 10, e0185817, 12.10.2017.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Dietary lactoferrin supplementation to gilts during gestation and lactation improves pig production and immunity

AU - Jahan, Marefa

AU - Kracht, Susie

AU - Ho, Yen

AU - Haque, Ziaul

AU - Bhattachatyya, Birendra N.

AU - Wynn, Peter C.

AU - Wang, Bing

PY - 2017/10/12

Y1 - 2017/10/12

N2 - Lactoferrin (LF), a sialylated iron-binding glycoprotein, performs multiple beneficial functions including modulating immunity and improves neurodevelopment, health and growth performance. Maternal LF intervention for gilts (first parity sows) on the performance of gilts and their offspring remains unknown. In the current study gilts were fed with a commercial pig feed supplemented with 1g LF /day (treatment group) or 1g milk casein/day (control group) from day 1 post mating throughout pregnancy and lactation for about 135 days. The milk production and body weight gain was monitored. The immunoglobulin concentrations in the serum of gilts and piglets were measured using ELISA. Our study showed that maternal LF supplementation to the gilt (1) significantly increased milk production at different time points (day 1, 3, 7 and 19) of lactation compared to the control (p<0.001); (2) significantly increased body weight gain of their piglets during the first 19 days of life compared to the control group (p<0.05); (3) tended to increase pregnancy rate, litter size and birth weight, number of piglets born alive, and decrease the number of dead and intrauterine growth restriction (IUGR) piglets; (4) significantly increased the concentration of serum IgA in gilt and serum sIgA in piglet (p<0.05). In summary, maternal Lf intervention in gilts can improve milk production, pig production and serum IgA and sIgA levels, and therefore plays a key role in shaping the performance of their progeny.

AB - Lactoferrin (LF), a sialylated iron-binding glycoprotein, performs multiple beneficial functions including modulating immunity and improves neurodevelopment, health and growth performance. Maternal LF intervention for gilts (first parity sows) on the performance of gilts and their offspring remains unknown. In the current study gilts were fed with a commercial pig feed supplemented with 1g LF /day (treatment group) or 1g milk casein/day (control group) from day 1 post mating throughout pregnancy and lactation for about 135 days. The milk production and body weight gain was monitored. The immunoglobulin concentrations in the serum of gilts and piglets were measured using ELISA. Our study showed that maternal LF supplementation to the gilt (1) significantly increased milk production at different time points (day 1, 3, 7 and 19) of lactation compared to the control (p<0.001); (2) significantly increased body weight gain of their piglets during the first 19 days of life compared to the control group (p<0.05); (3) tended to increase pregnancy rate, litter size and birth weight, number of piglets born alive, and decrease the number of dead and intrauterine growth restriction (IUGR) piglets; (4) significantly increased the concentration of serum IgA in gilt and serum sIgA in piglet (p<0.05). In summary, maternal Lf intervention in gilts can improve milk production, pig production and serum IgA and sIgA levels, and therefore plays a key role in shaping the performance of their progeny.

UR - http://www.scopus.com/inward/record.url?scp=85031096035&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85031096035&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0185817

DO - 10.1371/journal.pone.0185817

M3 - Article

C2 - 29023467

AN - SCOPUS:85031096035

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 10

M1 - e0185817

ER -