Differentiating grades of microglia activation with fractal analysis

Herbert Jelinek, Audrey Karperien, Terence Bossomaier, Alastair Buchan

Research output: Book chapter/Published conference paperConference paper

Abstract

Microglia affect and are sensitive to events in the central nervous system, changing in morphology and function as they respond to and resolve disruptions. Monitoring microglia is, therefore, an important goal of neuroscience. We investigated morphological changes in cultured mouse microglia, using the box counting fractal dimension (DB), lacunarity, and other measures. The DB and lacunarity corresponded well to visually applied classification systems of these cells. Complementing such systems, which depend on grossly visible differences between cells, the DB also differentiated between visually indistinguishable microglia in different functional states (i.e., deramifying versus reramifying). The results suggest that fractal analysis may help determine if a microglial cell is 'resting? rousing itself for action, acting subtly, or returning to a resting state. Because of the awesome potential microglia have to affect events in the central nervous system, the implications of this for the study of human health and disease are profound.
Original languageEnglish
Title of host publicationAsia-Pacific Conference on Complex Systems
EditorsWei Li
Place of PublicationQueensland, Australia
PublisherCentral Queensland University Australia
Pages12
Number of pages1
Volume12
ISBN (Electronic)1876674962
Publication statusPublished - 2004
Event7th Asia-Pacific Complex Systems Conference - Cairns, Australia, Australia
Duration: 06 Dec 200410 Dec 2004

Conference

Conference7th Asia-Pacific Complex Systems Conference
CountryAustralia
Period06/12/0410/12/04

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