Discovery and synthesis of Boletopsins 13 and 14, brominated fungal metabolites of terrestrial origin

Russell A Barrow, Andrew M Beekman, Stewart W Wossa, Oromo Kevo, Paul Ma

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Here we report the discovery and synthesis of complex polybrominated p-terphenyl ethers isolated from a mushroom (Boletopsis sp.) used as a traditional medicine by the Kiovi people in the highlands of Papua New Guinea. Boletopsins 13 and 14 represent the first report of polybrominated fungal metabolites to be produced by a terrestrial fungus. The synthetic method employs 2,4,4,6-tetrabromo-2,5-cyclohexadienone to achieve selective polybromination of the extended aromatic system in a selective and sequential manner.
Original languageEnglish
Pages (from-to)2133-2135
Number of pages3
JournalJournal of Natural Products
Volume78
Issue number8
Publication statusPublished - 2015

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