Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

Roman Fischer, David C Trudgian, Cynthia Wright, Gethin Thomas, Linda A Bradbury, Matthew A Brown, Paul Bowness, Benedikt M Kessler

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    Abstract

    Ankylosing Spondylitis (AS) is a common inflammatory rheumatic disease with a predilection for the axial skeleton,affecting 0.2% of the population. Current diagnostic criteria rely on a composite of clinical and radiological changes, with a mean time to diagnosis of 5 to 10 years. In this study we employed nano liquid-chromatography mass spectrometry analysis to detect and quantify proteins and small compounds including endogenous peptides and metabolites in serum from 18 AS patients and nine healthy individuals.
    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalMolecular and Cellular Proteomics
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 2012

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    Fischer, R., Trudgian, D. C., Wright, C., Thomas, G., Bradbury, L. A., Brown, M. A., Bowness, P., & Kessler, B. M. (2012). Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis. Molecular and Cellular Proteomics, 11(2), 1-11. https://doi.org/10.1074/ mcp.M111.013904