Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis

Roman Fischer, David C Trudgian, Cynthia Wright, Gethin Thomas, Linda A Bradbury, Matthew A Brown, Paul Bowness, Benedikt M Kessler

    Research output: Contribution to journalArticle

    55 Citations (Scopus)

    Abstract

    Ankylosing Spondylitis (AS) is a common inflammatory rheumatic disease with a predilection for the axial skeleton,affecting 0.2% of the population. Current diagnostic criteria rely on a composite of clinical and radiological changes, with a mean time to diagnosis of 5 to 10 years. In this study we employed nano liquid-chromatography mass spectrometry analysis to detect and quantify proteins and small compounds including endogenous peptides and metabolites in serum from 18 AS patients and nine healthy individuals.
    Original languageEnglish
    Pages (from-to)1-11
    Number of pages11
    JournalMolecular and Cellular Proteomics
    Volume11
    Issue number2
    DOIs
    Publication statusPublished - 2012

    Fingerprint

    Metabolomics
    Ankylosing Spondylitis
    Liquid chromatography
    Biomarkers
    Metabolites
    Proteomics
    Mass spectrometry
    Peptides
    Composite materials
    Rheumatic Diseases
    Serum
    Skeleton
    Liquid Chromatography
    Mass Spectrometry
    Proteins
    Population

    Cite this

    Fischer, Roman ; Trudgian, David C ; Wright, Cynthia ; Thomas, Gethin ; Bradbury, Linda A ; Brown, Matthew A ; Bowness, Paul ; Kessler, Benedikt M. / Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis. In: Molecular and Cellular Proteomics. 2012 ; Vol. 11, No. 2. pp. 1-11.
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    abstract = "Ankylosing Spondylitis (AS) is a common inflammatory rheumatic disease with a predilection for the axial skeleton,affecting 0.2{\%} of the population. Current diagnostic criteria rely on a composite of clinical and radiological changes, with a mean time to diagnosis of 5 to 10 years. In this study we employed nano liquid-chromatography mass spectrometry analysis to detect and quantify proteins and small compounds including endogenous peptides and metabolites in serum from 18 AS patients and nine healthy individuals.",
    author = "Roman Fischer and Trudgian, {David C} and Cynthia Wright and Gethin Thomas and Bradbury, {Linda A} and Brown, {Matthew A} and Paul Bowness and Kessler, {Benedikt M}",
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    Fischer, R, Trudgian, DC, Wright, C, Thomas, G, Bradbury, LA, Brown, MA, Bowness, P & Kessler, BM 2012, 'Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis', Molecular and Cellular Proteomics, vol. 11, no. 2, pp. 1-11. https://doi.org/10.1074/ mcp.M111.013904

    Discovery of candidate serum proteomic and metabolomic biomarkers in ankylosing spondylitis. / Fischer, Roman; Trudgian, David C; Wright, Cynthia; Thomas, Gethin; Bradbury, Linda A; Brown, Matthew A; Bowness, Paul; Kessler, Benedikt M.

    In: Molecular and Cellular Proteomics, Vol. 11, No. 2, 2012, p. 1-11.

    Research output: Contribution to journalArticle

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    AU - Bradbury, Linda A

    AU - Brown, Matthew A

    AU - Bowness, Paul

    AU - Kessler, Benedikt M

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    AB - Ankylosing Spondylitis (AS) is a common inflammatory rheumatic disease with a predilection for the axial skeleton,affecting 0.2% of the population. Current diagnostic criteria rely on a composite of clinical and radiological changes, with a mean time to diagnosis of 5 to 10 years. In this study we employed nano liquid-chromatography mass spectrometry analysis to detect and quantify proteins and small compounds including endogenous peptides and metabolites in serum from 18 AS patients and nine healthy individuals.

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