Drug Resistance Assays for Parasites

Nicholas Sangster, G. N. Maitland, S. Geerts, Saskia Decuypere, Jean-Claude Dujardin, J. A. Upcroft, P. Upcroft, M. Duraisingh

Research output: Book chapter/Published conference paperChapter (peer-reviewed)peer-review

Abstract

Drug resistance has become an increasingly serious and widespread problem worldwide, impacting across a broad phylogenetic range of important medical and veterinary parasite species. These include parasites from the groups of the Apicomplexa, the fl agellates and the helminths. Accurate measurement of resistance is vital for several reasons. In addition to making decisions on effective drug use for parasite control, resistance assays (sometimes called sensitivity assays) are also used to monitor prevalence, severity and dissemination of resistance and to evaluate the impact of control regimes on resistant parasites. In some cases they are used to assist the choice of drugs in clinical situations. A review of the assays currently available and knowledge of the information they provide gives a vital signpost of our current situation across a variety of parasite species and also as a guide in the design of future assays for resistances yet to develop.
Original languageEnglish
Title of host publicationAntimicrobial Drug Resistance
EditorsJ Knight J Knight, Douglas Mayers
Place of PublicationLondon
PublisherHumana Press
Pages1201-1225
Number of pages25
Volume2
Edition84 (Part L)
ISBN (Print)9781603275941
DOIs
Publication statusPublished - 2009

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