Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line

R. A. Hill; A. L. Strat; N. J. Hughes; T. J. Kokta; M. V. Dodson; A. Gertler

doi:10.1016/j.bbamcr.2004.08.005

Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line

R. A. Hill, A. L. Strat, N. J. Hughes, T. J. Kokta, M. V. Dodson, A. Gertler

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P

Original language	English
Pages (from-to)	205-211
Number of pages	7
Journal	Biochimica et Biophysica Acta - Molecular Cell Research
Volume	1693
Issue number	3
DOIs	https://doi.org/10.1016/j.bbamcr.2004.08.005
Publication status	Published - 2004

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title = "Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line",

abstract = "Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P",

author = "Hill, {R. A.} and Strat, {A. L.} and Hughes, {N. J.} and Kokta, {T. J.} and Dodson, {M. V.} and A. Gertler",

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doi = "10.1016/j.bbamcr.2004.08.005",

language = "English",

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AU - Hill, R. A.

AU - Strat, A. L.

AU - Hughes, N. J.

AU - Kokta, T. J.

AU - Dodson, M. V.

AU - Gertler, A.

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AB - Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P

U2 - 10.1016/j.bbamcr.2004.08.005

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IS - 3

ER -

Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line

Abstract

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