Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line

R. A. Hill, A. L. Strat, N. J. Hughes, T. J. Kokta, M. V. Dodson, A. Gertler

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P
Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1693
Issue number3
DOIs
Publication statusPublished - 2004

Fingerprint

Skeletal Muscle
Insulin
Cell Line
Threonine
Protein-Tyrosine Kinases
Serine
Tyrosine
Phosphorylation

Cite this

Hill, R. A. ; Strat, A. L. ; Hughes, N. J. ; Kokta, T. J. ; Dodson, M. V. ; Gertler, A. / Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line. In: Biochimica et Biophysica Acta - Molecular Cell Research. 2004 ; Vol. 1693, No. 3. pp. 205-211.
@article{8563ae25b5844ff1b8cdcaf19927e2ed,
title = "Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line",
abstract = "Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P",
author = "Hill, {R. A.} and Strat, {A. L.} and Hughes, {N. J.} and Kokta, {T. J.} and Dodson, {M. V.} and A. Gertler",
note = "Hill, RA Strat, AL Hughes, NJ Kokta, TJ Dodson, MV Gertler, A Hill, Rodney A/C-4106-2012 Hill, Rodney A/0000-0001-9990-1113 0006-3002",
year = "2004",
doi = "10.1016/j.bbamcr.2004.08.005",
language = "English",
volume = "1693",
pages = "205--211",
journal = "Biochimica et Biophysica Acta - Molecular Cell Research",
issn = "0167-4889",
publisher = "Elsevier",
number = "3",

}

Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line. / Hill, R. A.; Strat, A. L.; Hughes, N. J.; Kokta, T. J.; Dodson, M. V.; Gertler, A.

In: Biochimica et Biophysica Acta - Molecular Cell Research, Vol. 1693, No. 3, 2004, p. 205-211.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line

AU - Hill, R. A.

AU - Strat, A. L.

AU - Hughes, N. J.

AU - Kokta, T. J.

AU - Dodson, M. V.

AU - Gertler, A.

N1 - Hill, RA Strat, AL Hughes, NJ Kokta, TJ Dodson, MV Gertler, A Hill, Rodney A/C-4106-2012 Hill, Rodney A/0000-0001-9990-1113 0006-3002

PY - 2004

Y1 - 2004

N2 - Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P

AB - Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P

U2 - 10.1016/j.bbamcr.2004.08.005

DO - 10.1016/j.bbamcr.2004.08.005

M3 - Article

VL - 1693

SP - 205

EP - 211

JO - Biochimica et Biophysica Acta - Molecular Cell Research

JF - Biochimica et Biophysica Acta - Molecular Cell Research

SN - 0167-4889

IS - 3

ER -