Early insulin signaling cascade in a model of oxidative skeletal muscle: mouse Sol8 cell line

R. A. Hill, A. L. Strat, N. J. Hughes, T. J. Kokta, M. V. Dodson, A. Gertler

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Cell models provide important tools to investigate the mechanisms modulating the insulin-signaling cascade. Insulin interaction and subsequent signaling of cells is complex and regulated at multiple levels: receptor abundance, binding dynamics, phosphorylation/dephosphorylation of tyrosine and serine/threonine residues, and subsequent interactions of key intracellular messengers. We report early insulin signaling events in the mouse So18 myogenic cell line. So18 cells responded to insulin by increasing total IRS-1, p85 P13-kinase and tyrosine phosphorylated IRS-1 (pY-IRS-1) at 10 min (P
Original languageEnglish
Pages (from-to)205-211
Number of pages7
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1693
Issue number3
DOIs
Publication statusPublished - 2004

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