Effect of a seashell protein Haishengsu on the immunological function of mice with Ehrlich ascites tumor.

Guang-Yao Li, Ji-Zhu Liu, Shou-Geng Chen, Chun-Bo Wang, Bin Zhang, Lexin Wang

Research output: Contribution to journalArticle

6 Citations (Scopus)
9 Downloads (Pure)

Abstract

This study was designed to investigate the effect of a seashell protein Haishengsu (HSS) on the immuno logical function in mice with Ehrlich ascites tumor. Ehrlich ascites tumor-bearing mice were divided into three HSS groups (25, 50 and 100mg/kg, i.v., respectively), cyclophosphamide (10mg i.p.) and control group. The immunological function was assessed by measuring the phagocytizing capacity of the peritoneal macrophages and neutrophils, as well as the number of spleen hemolytic plaque-forming cells. The percentage of blood T-lymphocytes was also evaluated. The number and the percentage of phagocytizing macrophages and neutrophils in the 50 and 100mg/kg HSS groups were higher than in the control and the cyclophosphamide groups (P<0.01). The hemolytic plaque-forming cells in the three HSS groups (10.8±1.2, 16.9±3.9 and 25.3±2.9, respectively), was greater than in the control (7.3±1.4), or the cyclophosphamide group (0.33±0.4) (all P<0.01). In all HSS groups, the percentage of blood T3, T4 and T8 was higher than in the cyclophosphamide and the control group (all P<0.01). We conclude that HSS has significant immune-modulating effect in mice with Ehrlich ascites tumor.
Original languageEnglish
Pages (from-to)669-674
Number of pages6
JournalImmunopharmacology and Immunotoxicology
Volume31
Issue number4
DOIs
Publication statusPublished - Dec 2009

Fingerprint Dive into the research topics of 'Effect of a seashell protein Haishengsu on the immunological function of mice with Ehrlich ascites tumor.'. Together they form a unique fingerprint.

  • Cite this