Background: This study was designed to investigate the effect of captopril on the systolic pulmonary arterial pressure (PAP) and circulating endothelin-1 (ET-1) following surgical repair of tetralogy of Fallot (TOF).Methods and results: Seventy-six consecutive patients were divided into captopril and control group following successful repair of TOF. The captopril group was treated with oral captopril (0.2mg/kg/d) for 12 months. Venous blood was taken before and after the surgery for the analysis of ET-1. Systolic PAP and ventricular function was assessed by Doppler echocardiography.In the control group, there was an increase in ET-1 and systolic PAP following the surgery (P<0.05). In the captopril group, there was no significant increase in the systolic PAP and ET-1 during the 12-month follow up. The PAP and ET-1 values in the captopril group were lower than in the control group following the surgery (P<0.05).Conclusions: Systolic PAP is elevated following the complete surgical repair of TOF. Increased circulating ET-1 may be responsible for the elevation of PAP. Captopril treatment prevents post-surgical increases in systolic PAP and circulating ET-1.
Ma, Z., Ma, S-J., Dong, M-F., Wang, J-T., & Wang, L. (2009). Effect of captopril on pulmonary arterial pressure following corrective surgery for tetralogy of Fallot. Journal of Cardiac Surgery, 24(5), 553-557. https://doi.org/10.1111/j.1540-8191.2009.00873.x