Effect of captopril on pulmonary arterial pressure following corrective surgery for tetralogy of Fallot

Zeng-shan Ma, Sheng-Jun Ma, Ming-Feng Dong, Jian-Tang Wang, Lexin Wang

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: This study was designed to investigate the effect of captopril on the systolic pulmonary arterial pressure (PAP) and circulating endothelin-1 (ET-1) following surgical repair of tetralogy of Fallot (TOF).Methods and results: Seventy-six consecutive patients were divided into captopril and control group following successful repair of TOF. The captopril group was treated with oral captopril (0.2mg/kg/d) for 12 months. Venous blood was taken before and after the surgery for the analysis of ET-1. Systolic PAP and ventricular function was assessed by Doppler echocardiography.In the control group, there was an increase in ET-1 and systolic PAP following the surgery (P<0.05). In the captopril group, there was no significant increase in the systolic PAP and ET-1 during the 12-month follow up. The PAP and ET-1 values in the captopril group were lower than in the control group following the surgery (P<0.05).Conclusions: Systolic PAP is elevated following the complete surgical repair of TOF. Increased circulating ET-1 may be responsible for the elevation of PAP. Captopril treatment prevents post-surgical increases in systolic PAP and circulating ET-1.
Original languageEnglish
Pages (from-to)553-557
Number of pages5
JournalJournal of Cardiac Surgery
Volume24
Issue number5
DOIs
Publication statusPublished - Sep 2009

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