Effect of citrus flavonoids, naringin and naringenin, on metabolic syndrome and their mechanisms of action

Ashraful Alam, Nusrat Subhan, M. Mahbubur Rahman, Shaikh J. Uddin, Hasan Mahmud Reza, Satyajit D. Sarker

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222 Citations (Scopus)
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Abstract

Flavonoids are important natural compounds with diverse biologic activities. Citrus flavonoids constitute an important series of flavonoids. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities. Several lines of investigation suggest that naringin supplementation is beneficial for the treatment of obesity, diabetes, hypertension, and metabolic syndrome. A number of molecular mechanisms underlying its beneficial activities have been elucidated. However, their effect on obesity and metabolic disorder remains to be fully established. Moreover, the therapeutic uses of these flavonoids are significantly limited by the lack of adequate clinical evidence. This review aims to explore the biologic activities of these compounds, particularly on lipid metabolism in obesity, oxidative stress, and inflammation in context of metabolic syndrome.
Original languageEnglish
Pages (from-to)404-417
Number of pages14
JournalAdvances in nutrition (Bethesda, Md.)
Volume5
Issue number4
DOIs
Publication statusPublished - Jul 2014

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