Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model

Sokcheon Pak, Se-Eun Kim, Dong-Min Oh, Kyung Mi Shim, Moon Jin Jeong, Sung Chul Lim, Seung Yeol Nah, Soo Hyun Park, Seong Soo Kang, Chang Jong Moon, Jong Choon Kim, Sung Ho Kim, Chun Sik Bae

Research output: Contribution to journalArticle

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Abstract

Experimental induction of polycystic ovary (PCO) resembling some aspects of human PCO syndrome was produced using the long-acting compound estradiol valerate (EV). Our previous study on the role of Korean red ginseng total saponins in a steroid-induced PCO rat model demonstrated that electro-acupuncture modulates nerve growth factor (NGF) concentration in the ovaries. In fact, the involvement of a neurogenic component in the pathology of PCO-related ovarian dysfunction is preceded by an increase in sympathetic outflow to the ovaries. In the present study, we tested the hypothesis that Korean red ginseng extract (KRGE) administration modulates sympathetic nerve activity in rats with PCO. This was done by analyzing NGF protein and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. EV injection resulted in significantly higher ovarian NGF protein and NGF mRNA expression in PCO rats compared to control rats, and PCO ovaries were counteracted by KRGE administration with significantly lower expression of NGF protein and NGF mRNA compared to EV treated ovaries. These results indicate that EV modulates the neurotrophic state of the ovaries, which may be a component of the pathological process by which EV induces cyst formation and anovulation in rodents.
Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalArchives of Pharmacal Research
Volume32
Issue number3
DOIs
Publication statusPublished - 2009

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estradiol valerate
Panax
Nerve Growth Factor
Ovary
Steroids
Rats
Messenger RNA
Electroacupuncture
Rat control
Proteins
Saponins
Pathology
Anovulation
Polycystic Ovary Syndrome
Acupuncture
Pathologic Processes

Cite this

Pak, Sokcheon ; Kim, Se-Eun ; Oh, Dong-Min ; Shim, Kyung Mi ; Jeong, Moon Jin ; Lim, Sung Chul ; Nah, Seung Yeol ; Park, Soo Hyun ; Kang, Seong Soo ; Moon, Chang Jong ; Kim, Jong Choon ; Kim, Sung Ho ; Bae, Chun Sik. / Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model. In: Archives of Pharmacal Research. 2009 ; Vol. 32, No. 3. pp. 347-352.
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title = "Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model",
abstract = "Experimental induction of polycystic ovary (PCO) resembling some aspects of human PCO syndrome was produced using the long-acting compound estradiol valerate (EV). Our previous study on the role of Korean red ginseng total saponins in a steroid-induced PCO rat model demonstrated that electro-acupuncture modulates nerve growth factor (NGF) concentration in the ovaries. In fact, the involvement of a neurogenic component in the pathology of PCO-related ovarian dysfunction is preceded by an increase in sympathetic outflow to the ovaries. In the present study, we tested the hypothesis that Korean red ginseng extract (KRGE) administration modulates sympathetic nerve activity in rats with PCO. This was done by analyzing NGF protein and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. EV injection resulted in significantly higher ovarian NGF protein and NGF mRNA expression in PCO rats compared to control rats, and PCO ovaries were counteracted by KRGE administration with significantly lower expression of NGF protein and NGF mRNA compared to EV treated ovaries. These results indicate that EV modulates the neurotrophic state of the ovaries, which may be a component of the pathological process by which EV induces cyst formation and anovulation in rodents.",
author = "Sokcheon Pak and Se-Eun Kim and Dong-Min Oh and Shim, {Kyung Mi} and Jeong, {Moon Jin} and Lim, {Sung Chul} and Nah, {Seung Yeol} and Park, {Soo Hyun} and Kang, {Seong Soo} and Moon, {Chang Jong} and Kim, {Jong Choon} and Kim, {Sung Ho} and Bae, {Chun Sik}",
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Pak, S, Kim, S-E, Oh, D-M, Shim, KM, Jeong, MJ, Lim, SC, Nah, SY, Park, SH, Kang, SS, Moon, CJ, Kim, JC, Kim, SH & Bae, CS 2009, 'Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model', Archives of Pharmacal Research, vol. 32, no. 3, pp. 347-352. https://doi.org/10.1007/s12272-009-1306-y

Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model. / Pak, Sokcheon; Kim, Se-Eun; Oh, Dong-Min; Shim, Kyung Mi; Jeong, Moon Jin; Lim, Sung Chul; Nah, Seung Yeol; Park, Soo Hyun; Kang, Seong Soo; Moon, Chang Jong; Kim, Jong Choon; Kim, Sung Ho; Bae, Chun Sik.

In: Archives of Pharmacal Research, Vol. 32, No. 3, 2009, p. 347-352.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model

AU - Pak, Sokcheon

AU - Kim, Se-Eun

AU - Oh, Dong-Min

AU - Shim, Kyung Mi

AU - Jeong, Moon Jin

AU - Lim, Sung Chul

AU - Nah, Seung Yeol

AU - Park, Soo Hyun

AU - Kang, Seong Soo

AU - Moon, Chang Jong

AU - Kim, Jong Choon

AU - Kim, Sung Ho

AU - Bae, Chun Sik

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Archives of Pharmacal Research. ISSNs: 0253-6269;

PY - 2009

Y1 - 2009

N2 - Experimental induction of polycystic ovary (PCO) resembling some aspects of human PCO syndrome was produced using the long-acting compound estradiol valerate (EV). Our previous study on the role of Korean red ginseng total saponins in a steroid-induced PCO rat model demonstrated that electro-acupuncture modulates nerve growth factor (NGF) concentration in the ovaries. In fact, the involvement of a neurogenic component in the pathology of PCO-related ovarian dysfunction is preceded by an increase in sympathetic outflow to the ovaries. In the present study, we tested the hypothesis that Korean red ginseng extract (KRGE) administration modulates sympathetic nerve activity in rats with PCO. This was done by analyzing NGF protein and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. EV injection resulted in significantly higher ovarian NGF protein and NGF mRNA expression in PCO rats compared to control rats, and PCO ovaries were counteracted by KRGE administration with significantly lower expression of NGF protein and NGF mRNA compared to EV treated ovaries. These results indicate that EV modulates the neurotrophic state of the ovaries, which may be a component of the pathological process by which EV induces cyst formation and anovulation in rodents.

AB - Experimental induction of polycystic ovary (PCO) resembling some aspects of human PCO syndrome was produced using the long-acting compound estradiol valerate (EV). Our previous study on the role of Korean red ginseng total saponins in a steroid-induced PCO rat model demonstrated that electro-acupuncture modulates nerve growth factor (NGF) concentration in the ovaries. In fact, the involvement of a neurogenic component in the pathology of PCO-related ovarian dysfunction is preceded by an increase in sympathetic outflow to the ovaries. In the present study, we tested the hypothesis that Korean red ginseng extract (KRGE) administration modulates sympathetic nerve activity in rats with PCO. This was done by analyzing NGF protein and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. EV injection resulted in significantly higher ovarian NGF protein and NGF mRNA expression in PCO rats compared to control rats, and PCO ovaries were counteracted by KRGE administration with significantly lower expression of NGF protein and NGF mRNA compared to EV treated ovaries. These results indicate that EV modulates the neurotrophic state of the ovaries, which may be a component of the pathological process by which EV induces cyst formation and anovulation in rodents.

U2 - 10.1007/s12272-009-1306-y

DO - 10.1007/s12272-009-1306-y

M3 - Article

VL - 32

SP - 347

EP - 352

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

SN - 0253-6269

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