Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model

Sokcheon Pak, Se-Eun Kim, Dong-Min Oh, Kyung Mi Shim, Moon Jin Jeong, Sung Chul Lim, Seung Yeol Nah, Soo Hyun Park, Seong Soo Kang, Chang Jong Moon, Jong Choon Kim, Sung Ho Kim, Chun Sik Bae

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Abstract

Experimental induction of polycystic ovary (PCO) resembling some aspects of human PCO syndrome was produced using the long-acting compound estradiol valerate (EV). Our previous study on the role of Korean red ginseng total saponins in a steroid-induced PCO rat model demonstrated that electro-acupuncture modulates nerve growth factor (NGF) concentration in the ovaries. In fact, the involvement of a neurogenic component in the pathology of PCO-related ovarian dysfunction is preceded by an increase in sympathetic outflow to the ovaries. In the present study, we tested the hypothesis that Korean red ginseng extract (KRGE) administration modulates sympathetic nerve activity in rats with PCO. This was done by analyzing NGF protein and NGF mRNA expression involved in the pathophysiological process underlying steroid-induced PCO. EV injection resulted in significantly higher ovarian NGF protein and NGF mRNA expression in PCO rats compared to control rats, and PCO ovaries were counteracted by KRGE administration with significantly lower expression of NGF protein and NGF mRNA compared to EV treated ovaries. These results indicate that EV modulates the neurotrophic state of the ovaries, which may be a component of the pathological process by which EV induces cyst formation and anovulation in rodents.
Original languageEnglish
Pages (from-to)347-352
Number of pages6
JournalArchives of Pharmacal Research
Volume32
Issue number3
DOIs
Publication statusPublished - 2009

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    Pak, S., Kim, S-E., Oh, D-M., Shim, K. M., Jeong, M. J., Lim, S. C., Nah, S. Y., Park, S. H., Kang, S. S., Moon, C. J., Kim, J. C., Kim, S. H., & Bae, C. S. (2009). Effect of Korean red ginseng extract in a steroid-induced polycystic ovary murine model. Archives of Pharmacal Research, 32(3), 347-352. https://doi.org/10.1007/s12272-009-1306-y