Effect of procainamide on transmural ventricular repolarisation

Lexin Wang, Ah Chot Yong, David Kilpatrick

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

To investigate the pharmacological effect of procainamide on transmural ventricular repolarisation in normal heart, the transmural activation-recovery intervals (ARI) and their responses to procainamide (20 mg/min i.v. for 20 min) were studied in 6 open-chest, pentobarbitone-anaesthetised sheep. ARI was measured from the unipolar ECGs acquired with 4 plunge needles inserted into the basal and apical parts of the left ventricular wall. During sinus rhythm (cycle length 500'700 ms), there was no significant difference in the pooled ARI between the epicardium (266.0 ± 30.5 ms), midmyocardium (265.0 ± 28.9 ms) and endocardium (265.7 ± 28.1 ms) (p > 0.05). Procainamide prolonged ARI in all myocardial layers. The pooled ARI prolongation from the epicardium, midmyocardium and endocardium of the 6 animals was 66.8 ± 18.3, 70.3 ± 14.7 and 65.3 ± 15.7 ms (p > 0.05), respectively. In conclusion, sodium channel blocker procainamide results in a similar repolarisation prolongation in the left ventricular epicardium, midmyocardium and endocardium of a healthy heart.
Original languageEnglish
Pages (from-to)335-339
Number of pages5
JournalCardiovascular Drugs and Therapy
Volume16
Issue number4
DOIs
Publication statusPublished - 2002

Fingerprint Dive into the research topics of 'Effect of procainamide on transmural ventricular repolarisation'. Together they form a unique fingerprint.

  • Cite this