Effect of withholding macromolecules on the duration of intestinal permeability to colostral IgG in foals

S.L. Raidal, C. Mctaggart, J. Penhale

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To quantify absorption of colostral IgG by healthy neonatal foals and to test the hypothesis that delayed ingestion of macromolecules prolongs the duration of intestinal permeability to immunoglobulins (Ig) in newborn foals. Animals: Thirteen mixed breed foals. Procedure: Foals were randomly assigned to two treatment groups, which were fed either a glucose-electrolyte solution or a commercial milk replacer for 12 h after birth, before being fed a known amount of colostral IgG. A control group was fed a known amount of colostral IgG from birth. The efficiency of IgG absorption was calculated following determination of plasma IgG concentration for each foal. Results: Foals given colostrum immediately after birth transferred approximately 51% of ingested IgG into their vascular space. Delayed colostral ingestion significantly reduced the amount of IgG absorbed by foals. Withholding macromolecules for 12 h had no effect on the subsequent efficiency of IgG absorption. Conclusions: Colostrum should be supplied to foals within 12 h of birth for best uptake of Ig. The type of fluid administered to foals before the ingestion of colostrum does not influence subsequent absorption of Ig, suggesting that the process of gut closure in foals is not mediated by a finite capacity for macromolecular uptake.
Original languageEnglish
Pages (from-to)78-81
Number of pages4
JournalAustralian Veterinary Journal
Volume83
Issue number1-2
DOIs
Publication statusPublished - 2005

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foals
Permeability
permeability
Immunoglobulin G
duration
Colostrum
Parturition
Immunoglobulins
colostrum
Eating
immunoglobulins
ingestion
uptake mechanisms
milk replacer
Electrolytes
Blood Vessels
Milk
blood vessels
electrolytes
neonates

Cite this

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title = "Effect of withholding macromolecules on the duration of intestinal permeability to colostral IgG in foals",
abstract = "Objective: To quantify absorption of colostral IgG by healthy neonatal foals and to test the hypothesis that delayed ingestion of macromolecules prolongs the duration of intestinal permeability to immunoglobulins (Ig) in newborn foals. Animals: Thirteen mixed breed foals. Procedure: Foals were randomly assigned to two treatment groups, which were fed either a glucose-electrolyte solution or a commercial milk replacer for 12 h after birth, before being fed a known amount of colostral IgG. A control group was fed a known amount of colostral IgG from birth. The efficiency of IgG absorption was calculated following determination of plasma IgG concentration for each foal. Results: Foals given colostrum immediately after birth transferred approximately 51{\%} of ingested IgG into their vascular space. Delayed colostral ingestion significantly reduced the amount of IgG absorbed by foals. Withholding macromolecules for 12 h had no effect on the subsequent efficiency of IgG absorption. Conclusions: Colostrum should be supplied to foals within 12 h of birth for best uptake of Ig. The type of fluid administered to foals before the ingestion of colostrum does not influence subsequent absorption of Ig, suggesting that the process of gut closure in foals is not mediated by a finite capacity for macromolecular uptake.",
author = "S.L. Raidal and C. Mctaggart and J. Penhale",
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Effect of withholding macromolecules on the duration of intestinal permeability to colostral IgG in foals. / Raidal, S.L.; Mctaggart, C.; Penhale, J.

In: Australian Veterinary Journal, Vol. 83, No. 1-2, 2005, p. 78-81.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effect of withholding macromolecules on the duration of intestinal permeability to colostral IgG in foals

AU - Raidal, S.L.

AU - Mctaggart, C.

AU - Penhale, J.

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Australian Veterinary Journal. ISSNs: 0005-0423;

PY - 2005

Y1 - 2005

N2 - Objective: To quantify absorption of colostral IgG by healthy neonatal foals and to test the hypothesis that delayed ingestion of macromolecules prolongs the duration of intestinal permeability to immunoglobulins (Ig) in newborn foals. Animals: Thirteen mixed breed foals. Procedure: Foals were randomly assigned to two treatment groups, which were fed either a glucose-electrolyte solution or a commercial milk replacer for 12 h after birth, before being fed a known amount of colostral IgG. A control group was fed a known amount of colostral IgG from birth. The efficiency of IgG absorption was calculated following determination of plasma IgG concentration for each foal. Results: Foals given colostrum immediately after birth transferred approximately 51% of ingested IgG into their vascular space. Delayed colostral ingestion significantly reduced the amount of IgG absorbed by foals. Withholding macromolecules for 12 h had no effect on the subsequent efficiency of IgG absorption. Conclusions: Colostrum should be supplied to foals within 12 h of birth for best uptake of Ig. The type of fluid administered to foals before the ingestion of colostrum does not influence subsequent absorption of Ig, suggesting that the process of gut closure in foals is not mediated by a finite capacity for macromolecular uptake.

AB - Objective: To quantify absorption of colostral IgG by healthy neonatal foals and to test the hypothesis that delayed ingestion of macromolecules prolongs the duration of intestinal permeability to immunoglobulins (Ig) in newborn foals. Animals: Thirteen mixed breed foals. Procedure: Foals were randomly assigned to two treatment groups, which were fed either a glucose-electrolyte solution or a commercial milk replacer for 12 h after birth, before being fed a known amount of colostral IgG. A control group was fed a known amount of colostral IgG from birth. The efficiency of IgG absorption was calculated following determination of plasma IgG concentration for each foal. Results: Foals given colostrum immediately after birth transferred approximately 51% of ingested IgG into their vascular space. Delayed colostral ingestion significantly reduced the amount of IgG absorbed by foals. Withholding macromolecules for 12 h had no effect on the subsequent efficiency of IgG absorption. Conclusions: Colostrum should be supplied to foals within 12 h of birth for best uptake of Ig. The type of fluid administered to foals before the ingestion of colostrum does not influence subsequent absorption of Ig, suggesting that the process of gut closure in foals is not mediated by a finite capacity for macromolecular uptake.

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