Effects of Angiotensin Converting Enzyme Inhibition on Cardiac Innervation and Ventricular Arrhythmias after Myocardial Infarction

Su-Hua Yan, He-sheng Hu, Lexin Wang, Qi-chong Xing, Wen-juan Cheng, Mei Xue

Research output: Contribution to journalArticle

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Abstract

Purpose: To investigate the influence of angiotensin-converting enzyme inhibitor (ACEI) on cardiac innervation and inducible ventricular arrhythmias (VAs) in healed myocardial infarction (MI).Methods: Left anterior descending coronary artery was ligated to induce MI in 30 rabbits. After oral captopril (10mg/kg/d) for 8 weeks, electrophysiological study was performed to evaluate the incidence of inducible VAs. RT-PCR and immunohistochemistry were used to measure the cardiac innervation.Results: Eight weeks after the operation, the incidence of inducible VAs in MI-placebo group was significantly higher (58.3%, 7/12) than the sham operation group (16.7%, 2/12, P< 0.05). However, the inducible VAs in the MI-captopril group was lower (27.2%, 3/11) than the MI-placebo group (P<0.05). Proliferation and growth of nerve fibers in the MI-placebo group were mainly distributed at the periphery of the infarcted and perivascular regions of the myocardium. This MI-induced abnormal nerve fiber distribution was partly restored by the captopril treatment.Conclusion: Prolonged captopril treatment may be effective to prevent occurrence of VAs in healed MI, partly by attenuating the spatial heterogeneity of cardiac innervation.
Original languageEnglish
Pages (from-to)E198-E205
JournalClinical and Investigative Medicine
Volume31
Issue number4
Publication statusPublished - 2008

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Peptidyl-Dipeptidase A
Cardiac Arrhythmias
Myocardial Infarction
Captopril
Placebos
Nerve Fibers
Incidence
Angiotensin-Converting Enzyme Inhibitors
Coronary Vessels
Myocardium
Immunohistochemistry
Rabbits
Polymerase Chain Reaction
Therapeutics
Growth

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Yan, Su-Hua ; Hu, He-sheng ; Wang, Lexin ; Xing, Qi-chong ; Cheng, Wen-juan ; Xue, Mei. / Effects of Angiotensin Converting Enzyme Inhibition on Cardiac Innervation and Ventricular Arrhythmias after Myocardial Infarction. In: Clinical and Investigative Medicine. 2008 ; Vol. 31, No. 4. pp. E198-E205.
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title = "Effects of Angiotensin Converting Enzyme Inhibition on Cardiac Innervation and Ventricular Arrhythmias after Myocardial Infarction",
abstract = "Purpose: To investigate the influence of angiotensin-converting enzyme inhibitor (ACEI) on cardiac innervation and inducible ventricular arrhythmias (VAs) in healed myocardial infarction (MI).Methods: Left anterior descending coronary artery was ligated to induce MI in 30 rabbits. After oral captopril (10mg/kg/d) for 8 weeks, electrophysiological study was performed to evaluate the incidence of inducible VAs. RT-PCR and immunohistochemistry were used to measure the cardiac innervation.Results: Eight weeks after the operation, the incidence of inducible VAs in MI-placebo group was significantly higher (58.3{\%}, 7/12) than the sham operation group (16.7{\%}, 2/12, P< 0.05). However, the inducible VAs in the MI-captopril group was lower (27.2{\%}, 3/11) than the MI-placebo group (P<0.05). Proliferation and growth of nerve fibers in the MI-placebo group were mainly distributed at the periphery of the infarcted and perivascular regions of the myocardium. This MI-induced abnormal nerve fiber distribution was partly restored by the captopril treatment.Conclusion: Prolonged captopril treatment may be effective to prevent occurrence of VAs in healed MI, partly by attenuating the spatial heterogeneity of cardiac innervation.",
keywords = "Open access version available, Angiotensin-converting enzyme inhibitor, Cardiac innervation, Myocardial infarction, Ventricular arrhythmia",
author = "Su-Hua Yan and He-sheng Hu and Lexin Wang and Qi-chong Xing and Wen-juan Cheng and Mei Xue",
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Effects of Angiotensin Converting Enzyme Inhibition on Cardiac Innervation and Ventricular Arrhythmias after Myocardial Infarction. / Yan, Su-Hua; Hu, He-sheng; Wang, Lexin; Xing, Qi-chong; Cheng, Wen-juan; Xue, Mei.

In: Clinical and Investigative Medicine, Vol. 31, No. 4, 2008, p. E198-E205.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Effects of Angiotensin Converting Enzyme Inhibition on Cardiac Innervation and Ventricular Arrhythmias after Myocardial Infarction

AU - Yan, Su-Hua

AU - Hu, He-sheng

AU - Wang, Lexin

AU - Xing, Qi-chong

AU - Cheng, Wen-juan

AU - Xue, Mei

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Clinical and Investigative Medicine. ISSNs: 1488-2353;

PY - 2008

Y1 - 2008

N2 - Purpose: To investigate the influence of angiotensin-converting enzyme inhibitor (ACEI) on cardiac innervation and inducible ventricular arrhythmias (VAs) in healed myocardial infarction (MI).Methods: Left anterior descending coronary artery was ligated to induce MI in 30 rabbits. After oral captopril (10mg/kg/d) for 8 weeks, electrophysiological study was performed to evaluate the incidence of inducible VAs. RT-PCR and immunohistochemistry were used to measure the cardiac innervation.Results: Eight weeks after the operation, the incidence of inducible VAs in MI-placebo group was significantly higher (58.3%, 7/12) than the sham operation group (16.7%, 2/12, P< 0.05). However, the inducible VAs in the MI-captopril group was lower (27.2%, 3/11) than the MI-placebo group (P<0.05). Proliferation and growth of nerve fibers in the MI-placebo group were mainly distributed at the periphery of the infarcted and perivascular regions of the myocardium. This MI-induced abnormal nerve fiber distribution was partly restored by the captopril treatment.Conclusion: Prolonged captopril treatment may be effective to prevent occurrence of VAs in healed MI, partly by attenuating the spatial heterogeneity of cardiac innervation.

AB - Purpose: To investigate the influence of angiotensin-converting enzyme inhibitor (ACEI) on cardiac innervation and inducible ventricular arrhythmias (VAs) in healed myocardial infarction (MI).Methods: Left anterior descending coronary artery was ligated to induce MI in 30 rabbits. After oral captopril (10mg/kg/d) for 8 weeks, electrophysiological study was performed to evaluate the incidence of inducible VAs. RT-PCR and immunohistochemistry were used to measure the cardiac innervation.Results: Eight weeks after the operation, the incidence of inducible VAs in MI-placebo group was significantly higher (58.3%, 7/12) than the sham operation group (16.7%, 2/12, P< 0.05). However, the inducible VAs in the MI-captopril group was lower (27.2%, 3/11) than the MI-placebo group (P<0.05). Proliferation and growth of nerve fibers in the MI-placebo group were mainly distributed at the periphery of the infarcted and perivascular regions of the myocardium. This MI-induced abnormal nerve fiber distribution was partly restored by the captopril treatment.Conclusion: Prolonged captopril treatment may be effective to prevent occurrence of VAs in healed MI, partly by attenuating the spatial heterogeneity of cardiac innervation.

KW - Open access version available

KW - Angiotensin-converting enzyme inhibitor

KW - Cardiac innervation

KW - Myocardial infarction

KW - Ventricular arrhythmia

M3 - Article

VL - 31

SP - E198-E205

JO - Clinical and Investigative Medicine

JF - Clinical and Investigative Medicine

SN - 0147-958X

IS - 4

ER -