Effects of extract of Ginkgo biloba on intracranial pressure, cerebral perfusion pressure, and cerebral blood flow in a rat model of subarachnoid haemorrhage

Bao-liang Sun, Hui Yuan, Ming-Feng Yang, Zuo-Li Xia, Su-Ming Zhang, Lexin Wang

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Abstract

The purpose of this study was to investigate in effect of extract of Ginkgo biloba (EGb) on cerebral blood perfusion in a subarachnoid haemorrhage (SAH) rat model. SAH lead to an increase in intracranial pressure and decrease in cranial perfusion pressure and regional cerebral blood flow in all groups. However, the intracranial pressure increases in EGb groups were less than that of the vehicle group (p<0.01), whereas the reduction in cranial perfusion pressure and regional cerebral blood flow in the EGb group was less than that of the vehicle and SAH groups (p<0.01). We concluded that EGb attenuates the increase in intracranial pressure and reduction in cerebral blood perfusion after SAH.
Original languageEnglish
Pages (from-to)655-665
Number of pages11
JournalInternational Journal of Neuroscience
Volume117
Issue number5
DOIs
Publication statusPublished - 2007

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