TY - JOUR
T1 - Effects of Folic Acid on Cardiac Myocyte Apoptosis in Rats with Streptozotocin-induced Diabetes Mellitus
AU - Wu, Tong-guo
AU - Li, Wei-Hong
AU - Lin, Zi-Qing
AU - Wang, Lexin
N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Cardiovascular Drugs and Therapy. ISSNs: 0920-3206;
PY - 2008
Y1 - 2008
N2 - Backgrounds: The effect of folic acid on cardiac myocyte apoptosis secondary to diabetes is unknown.Methods: Diabetic rats were divided into diabetic control (DC, n=11), low-dose (LDF, 0.4mg/kg/day, n=12) and high-dose (HDF, 1.2mg/kg/day, n=12) folic acid groups. Non-diabetic rats (n=11) were used as the normal control (NC).Results: After 11 weeks of treatment, compared with the NC group, the DC group showed a reduced blood levels of reactive oxygen species (ROS, P<0.01). The rate of cardiac myocyte apoptosis in the diabetic control group was also greater than in the non-diabetic control group (P<0.01). In folic acid-treated rats, the blood levels of ROS was higher than in the diabetic control group (P<0.05). There was a dose-dependent reduction in the rate of cardiac myocyte apoptosis in the folic acid groups (P<0.01), and this was accompanied by an increased level of anti-apoptotic protein Bcl-2 and decreased level of pro-apoptotic protein Bax and Fas (P<0.01).Conclusions: Dietary folic acid supplementation diminishes the cardiac myocyte apoptosis in streptozotocin-induced diabetes. The apoptosis suppression is accompanied by an increase in the expression of Bcl-2 and a decrease in Bax and Fas.
AB - Backgrounds: The effect of folic acid on cardiac myocyte apoptosis secondary to diabetes is unknown.Methods: Diabetic rats were divided into diabetic control (DC, n=11), low-dose (LDF, 0.4mg/kg/day, n=12) and high-dose (HDF, 1.2mg/kg/day, n=12) folic acid groups. Non-diabetic rats (n=11) were used as the normal control (NC).Results: After 11 weeks of treatment, compared with the NC group, the DC group showed a reduced blood levels of reactive oxygen species (ROS, P<0.01). The rate of cardiac myocyte apoptosis in the diabetic control group was also greater than in the non-diabetic control group (P<0.01). In folic acid-treated rats, the blood levels of ROS was higher than in the diabetic control group (P<0.05). There was a dose-dependent reduction in the rate of cardiac myocyte apoptosis in the folic acid groups (P<0.01), and this was accompanied by an increased level of anti-apoptotic protein Bcl-2 and decreased level of pro-apoptotic protein Bax and Fas (P<0.01).Conclusions: Dietary folic acid supplementation diminishes the cardiac myocyte apoptosis in streptozotocin-induced diabetes. The apoptosis suppression is accompanied by an increase in the expression of Bcl-2 and a decrease in Bax and Fas.
KW - Open access version available
KW - Apoptosis
KW - Diabetes
KW - Folic acid
KW - Oxidative stress
KW - Streptozotocin
U2 - 10.1007/s10557-008-6109-8
DO - 10.1007/s10557-008-6109-8
M3 - Article
SN - 0920-3206
VL - 22
SP - 299
EP - 304
JO - Cardiovascular Drugs and Therapy
JF - Cardiovascular Drugs and Therapy
IS - 4
ER -
