Effects of testosterone on cytokines and left ventricular remodeling following heart failure

Yan-zhou Zhang, Xiao-wen Xing, Ben He, Lexin Wang

Research output: Contribution to journalArticle

22 Citations (Scopus)
19 Downloads (Pure)

Abstract

Aims: To investigate the effects of testosterone treatment on cytokines, ventricular remodeling in rats with heart failure.Materials and methods: Sprague-Dawley male rats with heart failure were divided into testosterone (n = 22) and placebo (n = 22) group. Pseudo surgery was performed on a third group of 15 male rats as control.Results: Compared with the placebo group, the testosterone group had a greater LVEF (P <0.05), a higher serum IL-10 level (P <0.05) and a lower serum TNF-α level (P<0.05). The expression of TNF-α mRNA, MMP-9 mRNA and the myocardial hydroxyproline contents in the testosterone group were also lower than in the placebo group (P<0.05). The mortality rate in the testosterone and placebo group was 31.8% and 68.2%, respectively (P <0.05).Conclusion: Serum testosterone levels were decreased significantly in male rats with heart failure. Testosterone treatment diminishes the imbalance between interleukin-10 and TNF-α, suppresses ventricular remodeling and improves cardiac function.
Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalCellular Physiology and Biochemistry
Volume20
Issue number6
DOIs
Publication statusPublished - 2007

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