TY - JOUR
T1 - Effects of transportation on gastric pH and gastric ulceration in mares
AU - Padalino, Barbara
AU - Davis, Georgina L.
AU - Raidal, Sharanne L.
N1 - Includes bibliographical references
PY - 2020/3
Y1 - 2020/3
N2 - Background: Transportation has been suggested as a risk factor for gastric ulceration in horses, but limited evidence supports this assumption. Animals: Twenty-six Standardbred, Thoroughbred, and Warmblood mares from a university teaching herd. Methods: Twelve mares were confined for 12 hours, overnight, in reproductive stocks with indwelling nasogastric tubes (NGTs) to assess pH of gastric fluid (GF). Gastric ulceration was assessed endoscopically before and after confinement. Subsequently, 26 horses were transported for 12 hours, overnight, in 2 consignments. During transportation, GF was aspirated from indwelling NGT placed in the same 12 mares used in the confinement study, and gastric ulceration was assessed endoscopically before and after transportation in all horses. Results: The median pH of GF in confined horses was 1.70-2.49 at each sampling point, and there was no apparent effect on gastric squamous ulcer scores. The median pH of GF from the same 12 horses at corresponding sampling times during transportation was 6.82-7.22. Transportation was associated with increased gastric squamous ulcer scores, particularly in horses fasted for gastroscopy and NGT placement immediately before departure. Gastric emptying appeared delayed after transportation in horses fed before departure. Conclusions and Clinical Importance: Transportation is associated with increased gastric squamous ulceration and with increased pH of GF. These findings may be a consequence of impaired gastric emptying and reflux of alkaline small intestinal content, with factors such as duodenal bile salts and short-chain fatty acids mediating mucosal injury.
AB - Background: Transportation has been suggested as a risk factor for gastric ulceration in horses, but limited evidence supports this assumption. Animals: Twenty-six Standardbred, Thoroughbred, and Warmblood mares from a university teaching herd. Methods: Twelve mares were confined for 12 hours, overnight, in reproductive stocks with indwelling nasogastric tubes (NGTs) to assess pH of gastric fluid (GF). Gastric ulceration was assessed endoscopically before and after confinement. Subsequently, 26 horses were transported for 12 hours, overnight, in 2 consignments. During transportation, GF was aspirated from indwelling NGT placed in the same 12 mares used in the confinement study, and gastric ulceration was assessed endoscopically before and after transportation in all horses. Results: The median pH of GF in confined horses was 1.70-2.49 at each sampling point, and there was no apparent effect on gastric squamous ulcer scores. The median pH of GF from the same 12 horses at corresponding sampling times during transportation was 6.82-7.22. Transportation was associated with increased gastric squamous ulcer scores, particularly in horses fasted for gastroscopy and NGT placement immediately before departure. Gastric emptying appeared delayed after transportation in horses fed before departure. Conclusions and Clinical Importance: Transportation is associated with increased gastric squamous ulceration and with increased pH of GF. These findings may be a consequence of impaired gastric emptying and reflux of alkaline small intestinal content, with factors such as duodenal bile salts and short-chain fatty acids mediating mucosal injury.
KW - alkaline reflux
KW - bile salts
KW - equine glandular gastric disease
KW - equine squamous gastric disease
KW - gastric emptying
KW - gastric ulcer syndrome
KW - gastrointestinal motility
KW - volatile fatty acids
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U2 - 10.1111/jvim.15698
DO - 10.1111/jvim.15698
M3 - Article
C2 - 32009244
AN - SCOPUS:85078832941
SN - 1939-1676
VL - 34
SP - 922
EP - 932
JO - Journal of Veterinary Internal Medicine
JF - Journal of Veterinary Internal Medicine
IS - 2
ER -