Objectives: To investigate the effects of Xuezhikang, an extract from Chinese red-yeast rice, on the proliferation and adhesive capacity of endothelial progenitor cells (EPCs) from the peripheral blood of patients with stable coronary artery disease.Methods: Mononuclear cells were isolated by density-gradient centrifugation from 20 patients. After four days in culture, the attached cells were treated with PBS (control, n=20) or different concentrations of Xuezhikang (50, 1125, 250 and 500 ng/ml, 20 samples per group) or atorvastatin (10 ng/ml, n=20) for additional three days. The numbers of the EPCs and their capacity of adhesion to extracellular matrix proteins were evaluated.Results: Compared to the control (167±36), the numbers of cultured EPCs in the Xuezhikang groups (205±28, 244±31, 283±42 and 334±43) were significantly increased (P<0.001) in a dose-dependent manner. The adherence capacities of the EPCs in the four Xuezhikang groups (51±9, 62±10, 71±11 and 83±12) were greater than the control group (41±7, P<0.001). Both the numbers (327±49) and adherence capacities (84±15) of the EPCs in the atorvastatin group were also increased in comparison with the control group (P<0.001), but these increases were similar to that in the 500 ng/ml Xuezhikang group (P>0.05).Conclusions: Xuezhikang enhances the proliferation and adhesive capacity of EPCs derived from the peripheral blood of the patients with stable coronary artery disease. These effects were similar between Xuezhikang and atorvastatin.
|Number of pages||8|
|Journal||Current Therapeutic Research - Clinical and Experimental|
|Publication status||Published - 2008|