Effects of xuezhikang on proliferation and adhesion capacity of cultured endothelial progenitor cells: An in vitro study

Xiang-Quan Kong, Meng-Zan Wang, Lexin Wang, Jing-Bo Kong, Xue-Wen Qi, Shuang-Feng Chen

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Abstract

Objectives: To investigate the effects of Xuezhikang, an extract from Chinese red-yeast rice, on the proliferation and adhesive capacity of endothelial progenitor cells (EPCs) from the peripheral blood of patients with stable coronary artery disease.Methods: Mononuclear cells were isolated by density-gradient centrifugation from 20 patients. After four days in culture, the attached cells were treated with PBS (control, n=20) or different concentrations of Xuezhikang (50, 1125, 250 and 500 ng/ml, 20 samples per group) or atorvastatin (10 ng/ml, n=20) for additional three days. The numbers of the EPCs and their capacity of adhesion to extracellular matrix proteins were evaluated.Results: Compared to the control (167±36), the numbers of cultured EPCs in the Xuezhikang groups (205±28, 244±31, 283±42 and 334±43) were significantly increased (P<0.001) in a dose-dependent manner. The adherence capacities of the EPCs in the four Xuezhikang groups (51±9, 62±10, 71±11 and 83±12) were greater than the control group (41±7, P<0.001). Both the numbers (327±49) and adherence capacities (84±15) of the EPCs in the atorvastatin group were also increased in comparison with the control group (P<0.001), but these increases were similar to that in the 500 ng/ml Xuezhikang group (P>0.05).Conclusions: Xuezhikang enhances the proliferation and adhesive capacity of EPCs derived from the peripheral blood of the patients with stable coronary artery disease. These effects were similar between Xuezhikang and atorvastatin.
Original languageEnglish
Pages (from-to)252-259
Number of pages8
JournalCurrent Therapeutic Research - Clinical and Experimental
Volume69
Issue number3
DOIs
Publication statusPublished - 2008

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