Efficacy of the EG95 hydatid vaccine in a macropodid host, the tammar wallaby

T.S. Barnes, L.A. Hinds, David Jenkins, G.T. Coleman, A.L. Colebrook, C.T. Kyngdon, C.G. Gauci, M.W. Lightowlers

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


In Australia, macropodids are common intermediate hosts for the cestode Echinococcus granulosus, and sylvatic transmission is maintained via wild dogs. The parasite causes mortality in a number of macropodid species and the sylvatic cycle provides a source of infection to domestic livestock and humans. We determined the efficacy of the hydatid vaccine, EG95 in the tammar wallaby, Macropus eugenii, challenging either 1 or 9 months post-vaccination. EG95 provides similar protection to that seen in sheep (96'100%). Control tammars were significantly more likely to become infected (odds ratio 29.44; CI 4.13, 209.97; P=0.001) and to develop more cysts (count ratio 26.69; CI 5.83, 122.19; P<0.001). The vaccination may be beneficial if administered pre-release in captive breeding programmes for endangered macropodids. Further work to develop oral delivery methods may enable vaccine administration of wild animals and thereby a reduction in sylvatic transmission.
Original languageEnglish
Pages (from-to)461-468
Number of pages8
Issue number4
Publication statusPublished - 2009


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