Elevated serum levels of advanced glycation end products and their monocyte receptors in patients with Type 2 diabetes

Xu-dong Su, Shou-she LI, Ya-qiang Tian, Zhao-yan Zhang, Guang-zhen Zhang, Lexin Wang

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

BACKGROUND AND AIMS: Animal experiments showed that interaction between advanced glycation end products (AGE) and their receptors (RAGE) play an important role in the pathogenesis of diabetic complications. Soluble RAGE (sRAGE) can function as a decoy for RAGE ligands. The present study aimed to examine the levels of AGEs, RAGE and sRAGE in patients with type 2 diabetes (T2D).METHODS: RAGE gene expression was determined by real-time PCR in 50 patients with T2D (27 men, mean age 52 ± 7.7 years) and 50 age-matched controls without T2D. Serum AGEs and sRAGEs were assayed by enzyme-linked immunosorbent assay (ELISA).RESULTS: Serum level of AGEs was increased in patients with T2D (10.35 ± 2.27 'g/mL vs.7.69 ± 0.56 'g/mL, p <0.05). sRAGE was decreased in patients with T2D (573.6 ± 172.5 pg/mL vs. 603.4 ± 120.8 pg/mL p <0.01). RAGE gene expression was higher in T2D than in controls (p <0.01). There was an association between monocyte RAGE and serum levels of AGEs in both T2D patients (r = 0.29, p = 0.03) and controls (r = 0.31, p = 0.02). Serum AGEs correlated with homeostasis model assessment of insulin resistance (HOMA-IR) in both patients with T2D (r = 0.322, p = 0.004) and controls (r = 0.281, p = 0.003).CONCLUSIONS: Serum AGEs and monocyte RAGE expression are increased in patients with T2D, whereas serum sRAGE is decreased. Pharmacological intervention on serum AGEs and sRAGE may be a potential therapy for diabetes.
Original languageEnglish
Pages (from-to)596-601
Number of pages6
JournalArchives of Medical Research
Volume42
Issue number7
DOIs
Publication statusPublished - 2011

Fingerprint Dive into the research topics of 'Elevated serum levels of advanced glycation end products and their monocyte receptors in patients with Type 2 diabetes'. Together they form a unique fingerprint.

Cite this