The genetic control of sickness symptoms to lipopolysaccharide (LPS) was studied in chicken lines divergently selected for high (HGPS) and low (LGPS) group productivity and survivability resulting from cannibalism and flightiness in colony cages and in a Dekalb XL (DXL) commercial line. Six-wk-old chicks were randomly assigned to control or experimental groups and were injected intravenously with Escherichia coli LPS (5 mg/kg BW) or distilled saline (control). Sickness responses were measured? at 6, 12, 24, 48 and 72 h following injection. Although LPS induced widespread sickness symptoms in all of the treated chicks, the reactions were in a genotypic- and phenotypic-dependent manner. Compared to both LGPS and DXL chicks, HGPS chicks had acute, transient behavioral and physical changes. (you may want to expand the results a bit here to say exactly what we found)The effects of heritable factors and LPS immune challenge on the differential responses between the present lines are discussed, which may reflect each line's unique adaptability to stress and resistance to infection and inflammation. The results suggest that the present chicken lines may provide a valuable animal model for investigating the effects of genetic-environmental interactions on the behavioral and physiological homeostasis in response to stress and disease.
|Number of pages||9|
|Publication status||Published - 2004|