Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis

Max C Lau, Patricia Keith, Mary-ellen Costello, Linda A Bradbury, Kelly A Hollis, Gethin P Thomas, Matthew A Brown, Tony J Kenna

    Research output: Other contribution to conferenceAbstract

    Abstract

    TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16×10-10). T-bet is implicated in both innate and adaptive arms of immunity. However, the role of T-bet in AS pathogenesis is unclear.
    Original languageEnglish
    Pages3407-3408
    Number of pages2
    Publication statusPublished - 10 Nov 2015
    EventACR/ARHP Annual Meeting - San Francisco, United States
    Duration: 05 Nov 201510 Nov 2015
    https://web.archive.org/web/20160319093523/http://acrabstracts.org/meetings/2015-acrarhp-annual-meeting/?viewby=number

    Conference

    ConferenceACR/ARHP Annual Meeting
    CountryUnited States
    CitySan Francisco
    Period05/11/1510/11/15
    Internet address

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