TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16×10-10). T-bet is implicated in both innate and adaptive arms of immunity. However, the role of T-bet in AS pathogenesis is unclear.
|Number of pages||2|
|Publication status||Published - 10 Nov 2015|
|Event||ACR/ARHP Annual Meeting - San Francisco, United States|
Duration: 05 Nov 2015 → 10 Nov 2015
|Conference||ACR/ARHP Annual Meeting|
|Period||05/11/15 → 10/11/15|
Lau, M. C., Keith, P., Costello, M., Bradbury, L. A., Hollis, K. A., Thomas, G. P., Brown, M. A., & Kenna, T. J. (2015). Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis. 3407-3408. Abstract from ACR/ARHP Annual Meeting, San Francisco, United States. http://acrabstracts.org/abstract/enhanced-expression-of-the-transcription-factor-t-bet-alters-pro-inflammatory-cytokine-profile-in-ankylosing-spondylitis/