Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis

Max C Lau; Patricia Keith; Mary-ellen Costello; Linda A Bradbury; Kelly A Hollis; Gethin P Thomas; Matthew A Brown; Tony J Kenna

Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis

Max C Lau, Patricia Keith, Mary-ellen Costello, Linda A Bradbury, Kelly A Hollis, Gethin P Thomas, Matthew A Brown, Tony J Kenna

University of Queensland

Research output: Other contribution to conference › Abstract › peer-review

Abstract

TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16×10-10). T-bet is implicated in both innate and adaptive arms of immunity. However, the role of T-bet in AS pathogenesis is unclear.

Original language	English
Pages	3407-3408
Number of pages	2
Publication status	Published - 10 Nov 2015
Event	ACR/ARHP Annual Meeting - San Francisco, United States Duration: 05 Nov 2015 → 10 Nov 2015 https://web.archive.org/web/20160319093523/http://acrabstracts.org/meetings/2015-acrarhp-annual-meeting/?viewby=number

Conference

Conference	ACR/ARHP Annual Meeting
Country/Territory	United States
City	San Francisco
Period	05/11/15 → 10/11/15
Internet address	https://web.archive.org/web/20160319093523/http://acrabstracts.org/meetings/2015-acrarhp-annual-meeting/?viewby=number

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Lau, M. C., Keith, P., Costello, M., Bradbury, L. A., Hollis, K. A., Thomas, G. P., Brown, M. A., & Kenna, T. J. (2015). Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis. 3407-3408. Abstract from ACR/ARHP Annual Meeting, San Francisco, California, United States. http://acrabstracts.org/abstract/enhanced-expression-of-the-transcription-factor-t-bet-alters-pro-inflammatory-cytokine-profile-in-ankylosing-spondylitis/

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title = "Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis",

abstract = "TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16×10-10). T-bet is implicated in both innate and adaptive arms of immunity. However, the role of T-bet in AS pathogenesis is unclear.",

author = "Lau, {Max C} and Patricia Keith and Mary-ellen Costello and Bradbury, {Linda A} and Hollis, {Kelly A} and Thomas, {Gethin P} and Brown, {Matthew A} and Kenna, {Tony J}",

year = "2015",

month = nov,

day = "10",

language = "English",

pages = "3407--3408",

note = "ACR/ARHP Annual Meeting ; Conference date: 05-11-2015 Through 10-11-2015",

url = "https://web.archive.org/web/20160319093523/http://acrabstracts.org/meetings/2015-acrarhp-annual-meeting/?viewby=number",

}

Lau, MC, Keith, P, Costello, M, Bradbury, LA, Hollis, KA, Thomas, GP, Brown, MA & Kenna, TJ 2015, 'Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis', ACR/ARHP Annual Meeting, San Francisco, United States, 05/11/15 - 10/11/15 pp. 3407-3408. <http://acrabstracts.org/abstract/enhanced-expression-of-the-transcription-factor-t-bet-alters-pro-inflammatory-cytokine-profile-in-ankylosing-spondylitis/>

TY - CONF

T1 - Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis

AU - Lau, Max C

AU - Keith, Patricia

AU - Costello, Mary-ellen

AU - Bradbury, Linda A

AU - Hollis, Kelly A

AU - Thomas, Gethin P

AU - Brown, Matthew A

AU - Kenna, Tony J

PY - 2015/11/10

Y1 - 2015/11/10

N2 - TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16×10-10). T-bet is implicated in both innate and adaptive arms of immunity. However, the role of T-bet in AS pathogenesis is unclear.

AB - TBX21 encodes T-bet, a T-box transcription factor, and lies within a locus with genome-wide significant association with AS (rs11657479, odds ratio=1.13, P=6.16×10-10). T-bet is implicated in both innate and adaptive arms of immunity. However, the role of T-bet in AS pathogenesis is unclear.

M3 - Abstract

SP - 3407

EP - 3408

T2 - ACR/ARHP Annual Meeting

Y2 - 5 November 2015 through 10 November 2015

ER -

Enhanced Expression of the Transcription Factor T-bet Alters Pro-inflammatory Cytokine Profile in Ankylosing Spondylitis

Abstract

Conference

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