Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

Yam Nath Paudel; Efthalia Angelopoulou; Christina Piperi; Vinod RMT Balasubramaniam; Iekhsan Othman; Mohd Farooq Shaikh

doi:10.1016/j.ejphar.2019.172487

Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

Yam Nath Paudel, Efthalia Angelopoulou, Christina Piperi, Vinod RMT Balasubramaniam, Iekhsan Othman, Mohd Farooq Shaikh

Science and Health

Research output: Contribution to journal › Review article › peer-review

138 Citations (Scopus)

Abstract

High mobility group box 1 (HMGB1) is a ubiquitous protein, released passively by necrotic tissues or secretedactively by stressed cells. Extracellular HMGB1 is a typical damage-associated molecular pattern (DAMP) molecule which generates different redox types through binding with several receptors and signalling molecules, aggravating a range of cellular responses, including inflammation. HMGB1 is reported to participate in the pathogenesis of inflammatory diseases, through the interaction with pivotal transmembrane receptors, including the receptor for advanced glycation end products (RAGE) and toll-like receptor-4 (TLR-4). This review aims to highlight the role of HMGB1 in the innate inflammatory response describing its interaction with several cofactors and receptors that coordinate its downstream effects. Novel and underexplored HMGB1 binding molecules that have been actively involved in HMGB1-mediated inflammatory diseases/conditions with therapeutic potential are further discussed

Original language	English
Article number	172487
Pages (from-to)	1-12
Number of pages	12
Journal	European Journal of Pharmacology
Volume	858
DOIs	https://doi.org/10.1016/j.ejphar.2019.172487
Publication status	Published - 05 Sept 2019

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10.1016/j.ejphar.2019.172487

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title = "Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling",

abstract = "High mobility group box 1 (HMGB1) is a ubiquitous protein, released passively by necrotic tissues or secretedactively by stressed cells. Extracellular HMGB1 is a typical damage-associated molecular pattern (DAMP) molecule which generates different redox types through binding with several receptors and signalling molecules, aggravating a range of cellular responses, including inflammation. HMGB1 is reported to participate in the pathogenesis of inflammatory diseases, through the interaction with pivotal transmembrane receptors, including the receptor for advanced glycation end products (RAGE) and toll-like receptor-4 (TLR-4). This review aims to highlight the role of HMGB1 in the innate inflammatory response describing its interaction with several cofactors and receptors that coordinate its downstream effects. Novel and underexplored HMGB1 binding molecules that have been actively involved in HMGB1-mediated inflammatory diseases/conditions with therapeutic potential are further discussed",

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author = "Paudel, {Yam Nath} and Efthalia Angelopoulou and Christina Piperi and Balasubramaniam, {Vinod RMT} and Iekhsan Othman and Shaikh, {Mohd Farooq}",

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AU - Paudel, Yam Nath

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AU - Piperi, Christina

AU - Balasubramaniam, Vinod RMT

AU - Othman, Iekhsan

AU - Shaikh, Mohd Farooq

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AB - High mobility group box 1 (HMGB1) is a ubiquitous protein, released passively by necrotic tissues or secretedactively by stressed cells. Extracellular HMGB1 is a typical damage-associated molecular pattern (DAMP) molecule which generates different redox types through binding with several receptors and signalling molecules, aggravating a range of cellular responses, including inflammation. HMGB1 is reported to participate in the pathogenesis of inflammatory diseases, through the interaction with pivotal transmembrane receptors, including the receptor for advanced glycation end products (RAGE) and toll-like receptor-4 (TLR-4). This review aims to highlight the role of HMGB1 in the innate inflammatory response describing its interaction with several cofactors and receptors that coordinate its downstream effects. Novel and underexplored HMGB1 binding molecules that have been actively involved in HMGB1-mediated inflammatory diseases/conditions with therapeutic potential are further discussed

KW - DAMP

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KW - Inflammation

KW - LPS

KW - Pro-inflammatory

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ER -

Enlightening the role of high mobility group box 1 (HMGB1) in inflammation: Updates on receptor signalling

Abstract

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