Ankylosing spondylitis (AS) is a common inflammatory arthritis affecting primarily the axial skeleton. IL23R is genetically associated with AS. This study was undertaken to investigate and characterize the role of interleukin-23 (IL-23) signaling in AS pathogenesis.
Kenna, T. J., Davidson, S. I., Duan, R., Bradbury, L. A., McFarlane, J., Smith, M., Weedon, H., Street, S., Thomas, R., Thomas, G. P., & Brown, M. A. (2012). Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis. Arthritis and Rheumatism, 64(5), 1420-1429. https://doi.org/10.1002/art.33507