Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis

Tony J Kenna, Stuart I Davidson, Ran Duan, Linda A Bradbury, Janelle McFarlane, Malcolm Smith, Helen Weedon, Shayna Street, Ranjeny Thomas, Gethin P Thomas, Matthew A. Brown

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    154 Citations (Scopus)

    Abstract

    Ankylosing spondylitis (AS) is a common inflammatory arthritis affecting primarily the axial skeleton. IL23R is genetically associated with AS. This study was undertaken to investigate and characterize the role of interleukin-23 (IL-23) signaling in AS pathogenesis.
    Original languageEnglish
    Pages (from-to)1420-1429
    Number of pages10
    JournalArthritis and Rheumatism
    Volume64
    Issue number5
    DOIs
    Publication statusPublished - 2012

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    Kenna, T. J., Davidson, S. I., Duan, R., Bradbury, L. A., McFarlane, J., Smith, M., Weedon, H., Street, S., Thomas, R., Thomas, G. P., & Brown, M. A. (2012). Enrichment of circulating interleukin-17-secreting interleukin-23 receptor-positive γ/δ T cells in patients with active ankylosing spondylitis. Arthritis and Rheumatism, 64(5), 1420-1429. https://doi.org/10.1002/art.33507