Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease

Zhixiu Li; Katelin Haynes; Gethin P Thomas; Tony J Kenna; Paul J Leo; Matthew A Brown

Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease

Zhixiu Li, Katelin Haynes, Gethin P Thomas, Tony J Kenna, Paul J Leo, Matthew A Brown

University of Queensland

Research output: Other contribution to conference › Poster › peer-review

Abstract

Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated SNPs do not directly affect protein-coding genes. Studies of disease- and trait-associated SNPs suggest they may act by affecting gene regulatory regions in specific cell types or tissues. Therefore, identifying the AS relevant cell types is crucial for further mechanistic studies.

Original language	English
Publication status	Published - 2016
Event	2016 ACR/ARHP Annual Meeting - Washington DC, United States Duration: 10 Nov 2016 → 15 Nov 2016 http://acrabstracts.org/meetings/2016-acrarhp-annual-meeting/

Conference

Conference	2016 ACR/ARHP Annual Meeting
Country/Territory	United States
City	Washington DC
Period	10/11/16 → 15/11/16
Internet address	http://acrabstracts.org/meetings/2016-acrarhp-annual-meeting/

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Li, Z., Haynes, K., Thomas, G. P., Kenna, T. J., Leo, P. J., & Brown, M. A. (2016). Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease. Poster session presented at 2016 ACR/ARHP Annual Meeting, Washington DC, Washington, United States. http://acrabstracts.org/abstract/epigenetic-and-expression-analysis-of-ankylosing-spondylitis-association-loci-point-to-key-cell-types-driving-disease/

@conference{48202e285ee64b878bc971d9a28bd231,

title = "Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease",

abstract = "Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated SNPs do not directly affect protein-coding genes. Studies of disease- and trait-associated SNPs suggest they may act by affecting gene regulatory regions in specific cell types or tissues. Therefore, identifying the AS relevant cell types is crucial for further mechanistic studies.",

author = "Zhixiu Li and Katelin Haynes and Thomas, {Gethin P} and Kenna, {Tony J} and Leo, {Paul J} and Brown, {Matthew A}",

year = "2016",

language = "English",

note = "2016 ACR/ARHP Annual Meeting ; Conference date: 10-11-2016 Through 15-11-2016",

url = "http://acrabstracts.org/meetings/2016-acrarhp-annual-meeting/",

}

Li, Z, Haynes, K, Thomas, GP, Kenna, TJ, Leo, PJ & Brown, MA 2016, 'Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease', 2016 ACR/ARHP Annual Meeting, Washington DC, United States, 10/11/16 - 15/11/16. <http://acrabstracts.org/abstract/epigenetic-and-expression-analysis-of-ankylosing-spondylitis-association-loci-point-to-key-cell-types-driving-disease/>

TY - CONF

T1 - Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease

AU - Li, Zhixiu

AU - Haynes, Katelin

AU - Thomas, Gethin P

AU - Kenna, Tony J

AU - Leo, Paul J

AU - Brown, Matthew A

PY - 2016

Y1 - 2016

N2 - Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated SNPs do not directly affect protein-coding genes. Studies of disease- and trait-associated SNPs suggest they may act by affecting gene regulatory regions in specific cell types or tissues. Therefore, identifying the AS relevant cell types is crucial for further mechanistic studies.

AB - Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated SNPs do not directly affect protein-coding genes. Studies of disease- and trait-associated SNPs suggest they may act by affecting gene regulatory regions in specific cell types or tissues. Therefore, identifying the AS relevant cell types is crucial for further mechanistic studies.

M3 - Poster

T2 - 2016 ACR/ARHP Annual Meeting

Y2 - 10 November 2016 through 15 November 2016

ER -

Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease

Abstract

Conference

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