Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease

Zhixiu Li, Katelin Haynes, Gethin P Thomas, Tony J Kenna, Paul J Leo, Matthew A Brown

    Research output: Other contribution to conferencePoster

    Abstract

    Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated SNPs do not directly affect protein-coding genes. Studies of disease- and trait-associated SNPs suggest they may act by affecting gene regulatory regions in specific cell types or tissues. Therefore, identifying the AS relevant cell types is crucial for further mechanistic studies.
    Original languageEnglish
    Publication statusPublished - 2016
    Event2016 ACR/ARHP Annual Meeting - Washington DC, United States
    Duration: 10 Nov 201615 Nov 2016
    http://acrabstracts.org/meetings/2016-acrarhp-annual-meeting/

    Conference

    Conference2016 ACR/ARHP Annual Meeting
    CountryUnited States
    CityWashington DC
    Period10/11/1615/11/16
    Internet address

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