Susceptibility to ankylosing spondylitis (AS) is primarily genetic; thus far 113 susceptibility variants for AS have been identified. However, most of the AS associated SNPs do not directly affect protein-coding genes. Studies of disease- and trait-associated SNPs suggest they may act by affecting gene regulatory regions in specific cell types or tissues. Therefore, identifying the AS relevant cell types is crucial for further mechanistic studies.
|Publication status||Published - 2016|
|Event||2016 ACR/ARHP Annual Meeting - Washington DC, United States|
Duration: 10 Nov 2016 → 15 Nov 2016
|Conference||2016 ACR/ARHP Annual Meeting|
|Period||10/11/16 → 15/11/16|
Li, Z., Haynes, K., Thomas, G. P., Kenna, T. J., Leo, P. J., & Brown, M. A. (2016). Epigenetic and Expression Analysis of Ankylosing Spondylitis Association Loci Point to Key Cell Types Driving Disease. Poster session presented at 2016 ACR/ARHP Annual Meeting, Washington DC, United States. http://acrabstracts.org/abstract/epigenetic-and-expression-analysis-of-ankylosing-spondylitis-association-loci-point-to-key-cell-types-driving-disease/