Erythrocyte Oxidative Damage in Chronic Fatigue Syndrome

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Abstract

BACKGROUND: It has been hypothesised that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both of these are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative damage in Chronic Fatigue Syndrome (CFS). METHODS: Reduced glutathione (GSH), malondialdehyde (MDA), methaemoglobin (metHb) and 2,3-diphosphoglyceric acid (2,3-DPG) were measured in patients suffering from CFS and healthy control subjects. Scanning electron microscopic studies of the erythrocytes from both groups were also carried out. RESULTS: There was evidence of oxidative damage in CFS with 2,3-DPG, metHb and MDA significantly increased. The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects. CONCLUSIONS: There is a strong likelihood that erythrocyte oxidative damage is the cause of the presence of stomatocytes. The results of this study provide further evidence for the role of free radicals in the pathogenesis of CFS and a link between erythrocyte metabolism and erythrocyte shape.
Original languageEnglish
Pages (from-to)94-98
Number of pages5
JournalArchives of Medical Research
Volume38
Issue number1
DOIs
Publication statusPublished - 2007

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Chronic Fatigue Syndrome
Erythrocytes
2,3-Diphosphoglycerate
Methemoglobin
Malondialdehyde
Erythrocyte Deformability
Oxidation-Reduction
Free Radicals
Glutathione
Healthy Volunteers
Electrons

Cite this

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title = "Erythrocyte Oxidative Damage in Chronic Fatigue Syndrome",
abstract = "BACKGROUND: It has been hypothesised that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both of these are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative damage in Chronic Fatigue Syndrome (CFS). METHODS: Reduced glutathione (GSH), malondialdehyde (MDA), methaemoglobin (metHb) and 2,3-diphosphoglyceric acid (2,3-DPG) were measured in patients suffering from CFS and healthy control subjects. Scanning electron microscopic studies of the erythrocytes from both groups were also carried out. RESULTS: There was evidence of oxidative damage in CFS with 2,3-DPG, metHb and MDA significantly increased. The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects. CONCLUSIONS: There is a strong likelihood that erythrocyte oxidative damage is the cause of the presence of stomatocytes. The results of this study provide further evidence for the role of free radicals in the pathogenesis of CFS and a link between erythrocyte metabolism and erythrocyte shape.",
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Erythrocyte Oxidative Damage in Chronic Fatigue Syndrome. / Richards, Ross; Wang, Lexin; Jelinek, Herbert.

In: Archives of Medical Research, Vol. 38, No. 1, 2007, p. 94-98.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Erythrocyte Oxidative Damage in Chronic Fatigue Syndrome

AU - Richards, Ross

AU - Wang, Lexin

AU - Jelinek, Herbert

N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Archives of Medical Research. ISSNs: 0188-4409;

PY - 2007

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N2 - BACKGROUND: It has been hypothesised that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both of these are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative damage in Chronic Fatigue Syndrome (CFS). METHODS: Reduced glutathione (GSH), malondialdehyde (MDA), methaemoglobin (metHb) and 2,3-diphosphoglyceric acid (2,3-DPG) were measured in patients suffering from CFS and healthy control subjects. Scanning electron microscopic studies of the erythrocytes from both groups were also carried out. RESULTS: There was evidence of oxidative damage in CFS with 2,3-DPG, metHb and MDA significantly increased. The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects. CONCLUSIONS: There is a strong likelihood that erythrocyte oxidative damage is the cause of the presence of stomatocytes. The results of this study provide further evidence for the role of free radicals in the pathogenesis of CFS and a link between erythrocyte metabolism and erythrocyte shape.

AB - BACKGROUND: It has been hypothesised that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both of these are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative damage in Chronic Fatigue Syndrome (CFS). METHODS: Reduced glutathione (GSH), malondialdehyde (MDA), methaemoglobin (metHb) and 2,3-diphosphoglyceric acid (2,3-DPG) were measured in patients suffering from CFS and healthy control subjects. Scanning electron microscopic studies of the erythrocytes from both groups were also carried out. RESULTS: There was evidence of oxidative damage in CFS with 2,3-DPG, metHb and MDA significantly increased. The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects. CONCLUSIONS: There is a strong likelihood that erythrocyte oxidative damage is the cause of the presence of stomatocytes. The results of this study provide further evidence for the role of free radicals in the pathogenesis of CFS and a link between erythrocyte metabolism and erythrocyte shape.

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