Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 94-98 |
| Number of pages | 5 |
| Journal | Archives of Medical Research |
| Volume | 38 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2007 |
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Erythrocyte Oxidative Damage in Chronic Fatigue Syndrome. / Richards, Ross; Wang, Lexin; Jelinek, Herbert.
In: Archives of Medical Research, Vol. 38, No. 1, 2007, p. 94-98.Research output: Contribution to journal › Article
TY - JOUR
T1 - Erythrocyte Oxidative Damage in Chronic Fatigue Syndrome
AU - Richards, Ross
AU - Wang, Lexin
AU - Jelinek, Herbert
N1 - Imported on 12 Apr 2017 - DigiTool details were: Journal title (773t) = Archives of Medical Research. ISSNs: 0188-4409;
PY - 2007
Y1 - 2007
N2 - BACKGROUND: It has been hypothesised that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both of these are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative damage in Chronic Fatigue Syndrome (CFS). METHODS: Reduced glutathione (GSH), malondialdehyde (MDA), methaemoglobin (metHb) and 2,3-diphosphoglyceric acid (2,3-DPG) were measured in patients suffering from CFS and healthy control subjects. Scanning electron microscopic studies of the erythrocytes from both groups were also carried out. RESULTS: There was evidence of oxidative damage in CFS with 2,3-DPG, metHb and MDA significantly increased. The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects. CONCLUSIONS: There is a strong likelihood that erythrocyte oxidative damage is the cause of the presence of stomatocytes. The results of this study provide further evidence for the role of free radicals in the pathogenesis of CFS and a link between erythrocyte metabolism and erythrocyte shape.
AB - BACKGROUND: It has been hypothesised that a link exists between erythrocyte metabolism (particularly redox metabolism) and erythrocyte shape and that both of these are related to erythrocyte deformability. The aim of this research is to confirm the results of earlier studies and to investigate a correlation between erythrocyte morphology and erythrocyte oxidative damage in Chronic Fatigue Syndrome (CFS). METHODS: Reduced glutathione (GSH), malondialdehyde (MDA), methaemoglobin (metHb) and 2,3-diphosphoglyceric acid (2,3-DPG) were measured in patients suffering from CFS and healthy control subjects. Scanning electron microscopic studies of the erythrocytes from both groups were also carried out. RESULTS: There was evidence of oxidative damage in CFS with 2,3-DPG, metHb and MDA significantly increased. The CFS patients in this study also had significantly more stomatocytes in their blood than the normal subjects. CONCLUSIONS: There is a strong likelihood that erythrocyte oxidative damage is the cause of the presence of stomatocytes. The results of this study provide further evidence for the role of free radicals in the pathogenesis of CFS and a link between erythrocyte metabolism and erythrocyte shape.
KW - Open access version available
KW - Biochemistry
KW - Erythrocyte
KW - Free Radicals
KW - Morphology
KW - Oxidative Damage
U2 - 10.1016/j.arcmed.2006.06.008
DO - 10.1016/j.arcmed.2006.06.008
M3 - Article
VL - 38
SP - 94
EP - 98
JO - Archivos de Investigacion Medica
JF - Archivos de Investigacion Medica
SN - 0188-4409
IS - 1
ER -