Establishing a reference range for oligodendroglioma classification using Higuchi Dimension analysis

Herbert Jelinek, Helmut Ahammer, Slade Matthews, Peter Succar, Craig S. McLachlan, Michael Buckland

Research output: Book chapter/Published conference paperConference paperpeer-review

3 Citations (Scopus)


Gliomas are the most common type of brain tumours in adults and a significant cause of cancer-related mortality. The 1p/19q chromosome deleted oligodendroglioma subtype has been shown to have a good prognosis following chemotherapy. However the subjectivity inherent with associated tissue features in classifying this tumour has led to some uncertainty in diagnosis and identifying optimal treatment options. This study investigated the use of the Higuchi dimension (DH) as a diagnostic tool to differentiate between the oligodendrogliomas with and without loss of heterozygosity (LOH & noLOH respectively). Sixty-five neurosurgical resection specimens were analysed. DH was lower in the LOH tissue (mean±sd; 1.69±0.01; CI:1.69-1.71; p<0.05) compared to the non-deletion group (1.83±0.04; CI: 1.81-1.85; p<0.05). Our results indicate that oligodendroglioma tissue showed scale invariance and that the complexity of the tissue as determined by the Higuchi dimension decreased with loss of genetic heterozygosity. Determination of the fractal dimension of gliomas provides an inexpensive and accurate alternative for classification of oligodendrogliomas.
Original languageEnglish
Title of host publicationProceedings of BioMed 2012
Place of PublicationAustralia
Number of pages4
Publication statusPublished - 2012
EventThe 9th IASTED International Conference on Biomechanical Engineering: BioMed 2012 - Grand Hotel Europa, Innsbruck, Austria
Duration: 15 Feb 201217 Feb 2012 (Call for papers)


ConferenceThe 9th IASTED International Conference on Biomechanical Engineering
Internet address


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