Evaluation of a monoclonal IgM antibody for purging of bone marrow for autologous transplantation

H Zola, A Potter, S H Neoh, C A Juttner, D N Haylock, A M Rice, E J Favaloro, A Kabral, K F Bradstock

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

A monoclonal antibody of the IgM class, reacting with the CD9 (p24) antigen is described. The antibody (FMC27) is cytotoxic against cells of the common type of acute lymphoblastic leukaemia (c-ALL), giving killing at higher dilutions than an IgG antibody (FMC8) against the same antigen. FMC27 and FMC8 recognise different epitopes, and FMC27 may thus be used in a cocktail together with FMC8 and an antibody against the c-ALL antigen, WM21. Furthermore, the IgM antibody can be coated directly onto magnetic microparticles for magnetic purging, unlike the IgG antibody which must be used in a two-layer procedure.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalBone Marrow Transplantation
Volume1
Issue number3
Publication statusPublished - Feb 1987

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