Evaluation of canine plasma cortisol and C-reactive protein as measures of post-surgical stress and tissue trauma

Research output: Other contribution to conferenceAbstract

Abstract

Post surgical stress and tissue trauma have increasingly been evaluated through blood cortisol and C-reactive protein (CRP) assays. Cortisol release has numerous triggers compared with CRP and no comparison has previously been made between the discriminating ability of the assays. Forty five bitches were ovariohysterectomized by either an experienced surgeon (8) or veterinary student (37) under standardised conditions. Blood samples collected pre, 2, 4 and 6 hours post operatively were analysed for cortisol and CRP. Surgery times were four times longer, anaesthesia times double, post operative temperatures lower, and estimated blood loss was three times greater for student sterilised dogs. CRP and cortisol was found to increase significantly over time for all animals. Bitches sterilised by inexperienced surgeons had a significantly greater rise in CRP at 4 and 6 hours post surgically (P=0.046). Serum cortisol was not significantly affected by surgeon experience (P=0.242), or any other outcome variables assessed. Inexperienced surgeons caused more tissue trauma due to long surgical times, larger wounds, more bleeding and less precise tissue handling than experienced surgeons. This difference was only discernable in serum CRP concentrations. It was concluded that serum CRP is a more discriminating marker than serum cortisol when assessing post surgical trauma. Blood cortisol concentration may still be a useful, if less precise, measure of assessing patient perceived post surgical stress in dogs, but it was clearly inferior to CRP in terms of identifying differences between surgical procedures in this study.
Original languageEnglish
Pages2
Number of pages1
Publication statusPublished - 2011
Event2011 ACVS Symposium - Chicago, Illinois, New Zealand
Duration: 03 Nov 201105 Nov 2011

Conference

Conference2011 ACVS Symposium
CountryNew Zealand
Period03/11/1105/11/11

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C-Reactive Protein
Hydrocortisone
Canidae
Wounds and Injuries
Blood Proteins
Dogs
Students
Operative Time
Anesthesia
Biomarkers
Surgeons
Hemorrhage
Temperature
Serum

Cite this

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title = "Evaluation of canine plasma cortisol and C-reactive protein as measures of post-surgical stress and tissue trauma",
abstract = "Post surgical stress and tissue trauma have increasingly been evaluated through blood cortisol and C-reactive protein (CRP) assays. Cortisol release has numerous triggers compared with CRP and no comparison has previously been made between the discriminating ability of the assays. Forty five bitches were ovariohysterectomized by either an experienced surgeon (8) or veterinary student (37) under standardised conditions. Blood samples collected pre, 2, 4 and 6 hours post operatively were analysed for cortisol and CRP. Surgery times were four times longer, anaesthesia times double, post operative temperatures lower, and estimated blood loss was three times greater for student sterilised dogs. CRP and cortisol was found to increase significantly over time for all animals. Bitches sterilised by inexperienced surgeons had a significantly greater rise in CRP at 4 and 6 hours post surgically (P=0.046). Serum cortisol was not significantly affected by surgeon experience (P=0.242), or any other outcome variables assessed. Inexperienced surgeons caused more tissue trauma due to long surgical times, larger wounds, more bleeding and less precise tissue handling than experienced surgeons. This difference was only discernable in serum CRP concentrations. It was concluded that serum CRP is a more discriminating marker than serum cortisol when assessing post surgical trauma. Blood cortisol concentration may still be a useful, if less precise, measure of assessing patient perceived post surgical stress in dogs, but it was clearly inferior to CRP in terms of identifying differences between surgical procedures in this study.",
keywords = "CRP, Cortisol: Surgery: Surgical Trauma, Stress",
author = "Jacob Michelsen and Jane Heller",
note = "Imported on 03 May 2017 - DigiTool details were: publisher = Veterinary Surgery: 2011. Event dates (773o) = 3-5 November 2011; Parent title (773t) = American College of Veterinary Surgeons Veterinary Symposium (ACVS). ISSNs: 1532-950X; ; 2011 ACVS Symposium ; Conference date: 03-11-2011 Through 05-11-2011",
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Evaluation of canine plasma cortisol and C-reactive protein as measures of post-surgical stress and tissue trauma. / Michelsen, Jacob; Heller, Jane.

2011. 2 Abstract from 2011 ACVS Symposium, New Zealand.

Research output: Other contribution to conferenceAbstract

TY - CONF

T1 - Evaluation of canine plasma cortisol and C-reactive protein as measures of post-surgical stress and tissue trauma

AU - Michelsen, Jacob

AU - Heller, Jane

N1 - Imported on 03 May 2017 - DigiTool details were: publisher = Veterinary Surgery: 2011. Event dates (773o) = 3-5 November 2011; Parent title (773t) = American College of Veterinary Surgeons Veterinary Symposium (ACVS). ISSNs: 1532-950X;

PY - 2011

Y1 - 2011

N2 - Post surgical stress and tissue trauma have increasingly been evaluated through blood cortisol and C-reactive protein (CRP) assays. Cortisol release has numerous triggers compared with CRP and no comparison has previously been made between the discriminating ability of the assays. Forty five bitches were ovariohysterectomized by either an experienced surgeon (8) or veterinary student (37) under standardised conditions. Blood samples collected pre, 2, 4 and 6 hours post operatively were analysed for cortisol and CRP. Surgery times were four times longer, anaesthesia times double, post operative temperatures lower, and estimated blood loss was three times greater for student sterilised dogs. CRP and cortisol was found to increase significantly over time for all animals. Bitches sterilised by inexperienced surgeons had a significantly greater rise in CRP at 4 and 6 hours post surgically (P=0.046). Serum cortisol was not significantly affected by surgeon experience (P=0.242), or any other outcome variables assessed. Inexperienced surgeons caused more tissue trauma due to long surgical times, larger wounds, more bleeding and less precise tissue handling than experienced surgeons. This difference was only discernable in serum CRP concentrations. It was concluded that serum CRP is a more discriminating marker than serum cortisol when assessing post surgical trauma. Blood cortisol concentration may still be a useful, if less precise, measure of assessing patient perceived post surgical stress in dogs, but it was clearly inferior to CRP in terms of identifying differences between surgical procedures in this study.

AB - Post surgical stress and tissue trauma have increasingly been evaluated through blood cortisol and C-reactive protein (CRP) assays. Cortisol release has numerous triggers compared with CRP and no comparison has previously been made between the discriminating ability of the assays. Forty five bitches were ovariohysterectomized by either an experienced surgeon (8) or veterinary student (37) under standardised conditions. Blood samples collected pre, 2, 4 and 6 hours post operatively were analysed for cortisol and CRP. Surgery times were four times longer, anaesthesia times double, post operative temperatures lower, and estimated blood loss was three times greater for student sterilised dogs. CRP and cortisol was found to increase significantly over time for all animals. Bitches sterilised by inexperienced surgeons had a significantly greater rise in CRP at 4 and 6 hours post surgically (P=0.046). Serum cortisol was not significantly affected by surgeon experience (P=0.242), or any other outcome variables assessed. Inexperienced surgeons caused more tissue trauma due to long surgical times, larger wounds, more bleeding and less precise tissue handling than experienced surgeons. This difference was only discernable in serum CRP concentrations. It was concluded that serum CRP is a more discriminating marker than serum cortisol when assessing post surgical trauma. Blood cortisol concentration may still be a useful, if less precise, measure of assessing patient perceived post surgical stress in dogs, but it was clearly inferior to CRP in terms of identifying differences between surgical procedures in this study.

KW - CRP

KW - Cortisol: Surgery: Surgical Trauma

KW - Stress

M3 - Abstract

SP - 2

ER -