Evaluation of the efficacy of emodepside+praziquantel topical solution against cestone (Dipylidium caninum, Taenia taeniaeformis, and Echinicoccus multilocularis) infections in cats

S.D. Charles, G. Altreuther, C.R. Reinemeyer, J. Buch, T. Settje, L. Cruthers, D.J. Kok, D.D Bowman, K.R. Kazacos, David Jenkins, E. Schein

Research output: Contribution to journalArticle

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Abstract

Emodepside+praziquantel topical solution was developed to provide broad-spectrum anthelmintic activity against gastrointestinal parasites in cats. Eight controlled studies were conducted to evaluate the efficacy of a topical solution of emodepside (3 mg/kg) and praziquantel (12 mg/kg) (Profender®, Bayer AG, Leverkusen, Germany) against feline infections with three species of cestodes. Studies featured naturally acquired infections of Dipylidium caninum or Taenia taeniaeformis, or experimental infections with Echinococcus multilocularis that were placebo-controlled, randomized and blinded. Cats were euthanatized and necropsied between 2 and 11 days after treatment, depending on the target parasite. The efficacy of emodepside+praziquantel topical solution was 100% against D. caninum and T. taeniaeformis, and 98.5- 100% against E. multilocularis. No significant systemic or local adverse reactions to treatment were noted in cats that received the combination. Topical treatment of cats with emodepside+praziquantel topical solution was safe and highly effective against cestode infections.
Original languageEnglish
Pages (from-to)33-40
Number of pages8
JournalParasitology Research
Volume97
Issue number(SUPP. 1)
DOIs
Publication statusPublished - 2005

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Dipylidium caninum
Taenia taeniaeformis
Taenia
praziquantel
Praziquantel
Cats
Echinococcus multilocularis
cats
Infection
infection
Parasites
Cestode Infections
cestode infections
Cestoda
Anthelmintics
Felidae
parasites
Germany
anthelmintics
Therapeutics

Cite this

Charles, S.D. ; Altreuther, G. ; Reinemeyer, C.R. ; Buch, J. ; Settje, T. ; Cruthers, L. ; Kok, D.J. ; Bowman, D.D ; Kazacos, K.R. ; Jenkins, David ; Schein, E. / Evaluation of the efficacy of emodepside+praziquantel topical solution against cestone (Dipylidium caninum, Taenia taeniaeformis, and Echinicoccus multilocularis) infections in cats. In: Parasitology Research. 2005 ; Vol. 97, No. (SUPP. 1). pp. 33-40.
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Evaluation of the efficacy of emodepside+praziquantel topical solution against cestone (Dipylidium caninum, Taenia taeniaeformis, and Echinicoccus multilocularis) infections in cats. / Charles, S.D.; Altreuther, G.; Reinemeyer, C.R.; Buch, J.; Settje, T.; Cruthers, L.; Kok, D.J.; Bowman, D.D; Kazacos, K.R.; Jenkins, David; Schein, E.

In: Parasitology Research, Vol. 97, No. (SUPP. 1), 2005, p. 33-40.

Research output: Contribution to journalArticle

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