TY - JOUR
T1 - Exploring the neuroinflammatory pathway in epilepsy and cognitive impairment
T2 - Role of HMGB1 and translational challenges
AU - Ngadimon, Irma Wati
AU - Seth, Eryse Amira
AU - Shaikh, Mohd Farooq
N1 - © 2024 The Author(s). Published by IMR Press.
PY - 2024/6/24
Y1 - 2024/6/24
N2 - Neuroinflammation has emerged as a shared molecular mechanism in epilepsy and cognitive impairment, offering new insights into the complex interplay between immune responses and brain function. Evidence reveals involvement of High mobility group box 1 (HMGB1) in blood-brain barrier disruption and correlations with epilepsy severity and drug resistance. While anti-inflammatory treatments show promise, translating these discoveries faces challenges in elucidating mechanisms and developing reliable biomarkers. However, strategically targeting neuroinflammation and HMGB1-mediated inflammation holds therapeutic potential. This review synthesises knowledge on HMGB1 and related biomarkers in epilepsy and cognitive impairment to shape future research and treatments targeting these intricate inflammatory processes.
AB - Neuroinflammation has emerged as a shared molecular mechanism in epilepsy and cognitive impairment, offering new insights into the complex interplay between immune responses and brain function. Evidence reveals involvement of High mobility group box 1 (HMGB1) in blood-brain barrier disruption and correlations with epilepsy severity and drug resistance. While anti-inflammatory treatments show promise, translating these discoveries faces challenges in elucidating mechanisms and developing reliable biomarkers. However, strategically targeting neuroinflammation and HMGB1-mediated inflammation holds therapeutic potential. This review synthesises knowledge on HMGB1 and related biomarkers in epilepsy and cognitive impairment to shape future research and treatments targeting these intricate inflammatory processes.
KW - HMGB1 Protein/metabolism
KW - Humans
KW - Epilepsy/immunology
KW - Cognitive Dysfunction/metabolism
KW - Neuroinflammatory Diseases/metabolism
KW - Animals
KW - Blood-Brain Barrier/metabolism
KW - Biomarkers/metabolism
KW - Translational Research, Biomedical/methods
KW - Inflammation/metabolism
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85197135006&origin=inward
U2 - 10.31083/j.fbl2906229
DO - 10.31083/j.fbl2906229
M3 - Review article
C2 - 38940048
SN - 2768-6701
VL - 29
SP - 1
EP - 12
JO - Frontiers in Bioscience - Landmark
JF - Frontiers in Bioscience - Landmark
IS - 6
M1 - 229
ER -
