Expression profiling in spondylarthropy synovial biopsies highlights inflammatory gene changes in conjunction with altered Wnt signalling

G Thomas, R Duan, H Weedon, E Maylin, A Pettit, Malcolm Smith, Matthew Brown

    Research output: Other contribution to conferenceAbstract

    Abstract

    Gene expression profiling can provide valuable insights into the pathways mediating disease pathology. Many expression profiling studies in ankylosing spondylitis (AS) have focused on peripheral blood due to the scarcity of clinically relevant samples from affected joints. Specifically targeting the actual local sites of disease activity can generate valuable insights into cellular activity underlying the severe damage occurring in the joints in AS due to excessive bone formation. By undertaking a study in knee synovial biopsies from spondylarthropy (SpA) and ankylosing spondylitis (AS) patients we identified candidate genes and pathways that might mediate the systemic inflammation in the joints and contribute to the tissue damage and osteoproliferation.
    Original languageEnglish
    Pages1
    Number of pages1
    Publication statusPublished - 11 Apr 2012
    EventAustralian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting - Canberra, Australia
    Duration: 11 May 201214 May 2012
    http://onlinelibrary.wiley.com/doi/10.1111/j.1445-5994.2012.02759.x/pdf

    Conference

    ConferenceAustralian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting
    CountryAustralia
    CityCanberra
    Period11/05/1214/05/12
    Internet address

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  • Cite this

    Thomas, G., Duan, R., Weedon, H., Maylin, E., Pettit, A., Smith, M., & Brown, M. (2012). Expression profiling in spondylarthropy synovial biopsies highlights inflammatory gene changes in conjunction with altered Wnt signalling. 1. Abstract from Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia.