Gene expression profiling can provide valuable insights into the pathways mediating disease pathology. Many expression profiling studies in ankylosing spondylitis (AS) have focused on peripheral blood due to the scarcity of clinically relevant samples from affected joints. Specifically targeting the actual local sites of disease activity can generate valuable insights into cellular activity underlying the severe damage occurring in the joints in AS due to excessive bone formation. By undertaking a study in knee synovial biopsies from spondylarthropy (SpA) and ankylosing spondylitis (AS) patients we identified candidate genes and pathways that might mediate the systemic inflammation in the joints and contribute to the tissue damage and osteoproliferation.
|Number of pages||1|
|Publication status||Published - 11 Apr 2012|
|Event||Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting - Canberra, Australia|
Duration: 11 May 2012 → 14 May 2012
|Conference||Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting|
|Period||11/05/12 → 14/05/12|
Thomas, G., Duan, R., Weedon, H., Maylin, E., Pettit, A., Smith, M., & Brown, M. (2012). Expression profiling in spondylarthropy synovial biopsies highlights inflammatory gene changes in conjunction with altered Wnt signalling. 1. Abstract from Australian Rheumatology Association in conjunction with Rheumatology Health Professionals 53rd Annual Scientific Meeting, Canberra, Australia.