Extract of ginkgo biloba promotes the expression of VEGF Following Subarachnoid Hemorrhage in Rats

Bao-Liang Sun, Dong-mei Hu, Hui Yuan, Wen-Jin Ye, Xin-cheng Wang, Zuo-li Xia Xia, Su-ming Zhang Zhang, Lexin Wang

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
35 Downloads (Pure)

Abstract

The study aimed to investigate the effect of extract of Ginkgo biloba (EGb) on the expression of vascular endothelial growth factor (VEGF) after subarachnoid hemorrhage (SAH). Wistar rats were divided into non-SAH, SAH, vehicle, EGb1 (low dose), and EGb2 (high dose) groups. VEGF mRNA and VEGF protein were measured from brain tissues. The expressions of VEGF mRNA in SAH and vehicle groups were enhanced 24 and 72 hours after the establishment of SAH. Increased VEGF positive cells were found in the brain tissues in SAH and vehicle groups. The expressions of VEGF mRNA and VEGF protein were further increased by the pretreatment of EGb. We concluded that EGb exerts protective effects on secondary cerebral ischemic injury after SAH via the promotion of the expression of VEGF.
Original languageEnglish
Pages (from-to)995-1005
Number of pages11
JournalInternational Journal of Neuroscience
Volume119
Issue number7
DOIs
Publication statusPublished - 2009

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