Extracts of common pulses demonstrate potent in vitro anti-adipogenic properties

Kyle Reynolds, Jenny Wood, Fang Wang, Zhong Kai Zhou, Christopher Blanchard, Padraig Strappe

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Pulses are an important food source in many countries and also widely used as feed for livestock. Discovery of novel health benefits in pulses may contribute to improved diet and potential added value to crops. In this study, we examined the ability of extracts from faba bean, field pea and chickpea to inhibit the formation of fat droplets in an in vitro cell culture system that mimics the process of fat cell formation or adipogenesis. Both seed and hull extracts of all three pulses showed an inhibition of adipogenesis and the hull fraction and also contained higher levels of polyphenols compared with the seed extracts. At the molecular level, adipogenic inhibition was associated with a marked reduction in peroxisome proliferator-activated receptor gamma (PPARG) gene expression. Furthermore, the field pea pulse extract was shown to inhibit pancreatic lipase activity at a similar level to the drug 'orlistat', which is commonly used to treat obesity. Inhibition of adipogenesis by pulse extracts. International Journal of Food Science and Technology

Original languageEnglish
Pages (from-to)1327-1337
Number of pages11
JournalInternational Journal of Food Science and Technology
Issue number6
Publication statusPublished - 01 Jun 2016


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