TY - JOUR
T1 - Fabrication, structure, and function evaluation of the ferritin based nano-carrier for food bioactive compounds
AU - Liu, Yuqian
AU - Yang, Rui
AU - Liu, Jinguang
AU - Meng, D.
AU - Zhou, Zhongkai
AU - Zhang, Yuyu
AU - Blanchard, C.
PY - 2019/11/30
Y1 - 2019/11/30
N2 - The low solubility, instability, and low bioavailability of food bioactive compounds such as polyphenols and flavonoids, restrict their applications in the fields of food science and nutrition. Ferritin protein has received more and more attention in encapsulation and delivery of the bioactive compounds due to its nanosized shell-like structure and its reversible self-assembly character. After encapsulation, bioactive compounds can be functionalized by the ferritin vehicle to achieve stabilization, solubilization, and targeted delivery. In addition, the outer interfaces and the porous structure of ferritin are also artfully harnessed for encapsulation. This review focuses on the newest advances in the fabrication, characterization, and application of ferritin-based nano-carriers for bioactive compounds by the reversible self-assembly, outer-interface decoration methods, and the channel-directed approach. The functional improvements of food bioactive compounds, including their solubility, stability, and cellular uptake, are emphasized. The limitations that affect ferritin encapsulation are also examined.
AB - The low solubility, instability, and low bioavailability of food bioactive compounds such as polyphenols and flavonoids, restrict their applications in the fields of food science and nutrition. Ferritin protein has received more and more attention in encapsulation and delivery of the bioactive compounds due to its nanosized shell-like structure and its reversible self-assembly character. After encapsulation, bioactive compounds can be functionalized by the ferritin vehicle to achieve stabilization, solubilization, and targeted delivery. In addition, the outer interfaces and the porous structure of ferritin are also artfully harnessed for encapsulation. This review focuses on the newest advances in the fabrication, characterization, and application of ferritin-based nano-carriers for bioactive compounds by the reversible self-assembly, outer-interface decoration methods, and the channel-directed approach. The functional improvements of food bioactive compounds, including their solubility, stability, and cellular uptake, are emphasized. The limitations that affect ferritin encapsulation are also examined.
KW - Food bioactive compounds
KW - Nano-encapsulation
KW - Porous structure
KW - Protein cage
KW - Reversible assembly
KW - Surface decoration
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U2 - 10.1016/j.foodchem.2019.125097
DO - 10.1016/j.foodchem.2019.125097
M3 - Review article
C2 - 31284242
AN - SCOPUS:85068407861
SN - 0308-8146
VL - 299
SP - 1
EP - 10
JO - Food Chemistry
JF - Food Chemistry
M1 - 125097
ER -