Factors associated with survival and return to function following synovial infections in horses

Dani Crosby, Raphael Labens, Kris Hughes, Sharon Nielson, Bryan Hilbert

Research output: Contribution to journalArticle

Abstract

Synovial infections (SI) are common in horses of all ages and can be associated withhigh rates of morbidity and mortality. Identifying factors influencing survival and returnto function may be useful for management of affected individuals and determinationof prognosis. The objectives of this study were to identify factors associated withsurvival and return to function of horses and foals with SI presented to an equinehospital. This study is a retrospective case series. Data were collected from medicalrecords of all horses with SI that were presented to a single equine hospital betweenApril 1st, 2008 and May 1st, 2017. Long–term follow up was obtained by a semistructured telephone questionnaire of clinical outcomes and analysis of online racerecords. Univariate models were created using generalized linear and linear mixed modelsto assess factors associated with outcomes. Multivariable models were created usinggeneralized linear and linear mixed models to determine factors significantly associatedwith outcomes. Of 186 horses presented with SI, 161/186 (86.6%) were treated and145/161 (90.1%) survived to discharge. The majority of joints were treated with synoviallavage (93.8%). One hundred and twenty horses were included in the return to functionanalysis and 79 (65%) returned to function. Increasing number of days of treatmentwith systemic antimicrobials was associated with increased likelihood of survival foreach horse (OR 1.15, 95% CI 1.04−1.27, P = 0.025) and when considering eachindividual synovial structure (OR 1.11, 95% CI 1.04−1.17, P = 0.004). Horses treatedwith doxycycline were less likely to return to function (OR 0.39, 95% CI 0.19−0.8, P =0.031). The overall rate of survival of horses treated with SI is good. The likelihood ofreturn to function is lower than for survival. The findings of this study, combined withrelevant antimicrobial stewardship practices, can be used as a part of evidence-baseddecision-making when veterinarians are treating horses with SI.
Original languageEnglish
Article number367
Pages (from-to)1-9
Number of pages9
JournalFrontiers in Veterinary Science
Volume6
DOIs
Publication statusPublished - 22 Oct 2019

Fingerprint

Horses
horses
Infection
infection
anti-infective agents
doxycycline
Veterinarians
Doxycycline
Telephone
joints (animal)
foals
prognosis
veterinarians
morbidity
Linear Models
questionnaires
Joints
survival rate
Morbidity
Mortality

Cite this

@article{ec0648bdd7f4466fa3b36de50018fad9,
title = "Factors associated with survival and return to function following synovial infections in horses",
abstract = "Synovial infections (SI) are common in horses of all ages and can be associated withhigh rates of morbidity and mortality. Identifying factors influencing survival and returnto function may be useful for management of affected individuals and determinationof prognosis. The objectives of this study were to identify factors associated withsurvival and return to function of horses and foals with SI presented to an equinehospital. This study is a retrospective case series. Data were collected from medicalrecords of all horses with SI that were presented to a single equine hospital betweenApril 1st, 2008 and May 1st, 2017. Long–term follow up was obtained by a semistructured telephone questionnaire of clinical outcomes and analysis of online racerecords. Univariate models were created using generalized linear and linear mixed modelsto assess factors associated with outcomes. Multivariable models were created usinggeneralized linear and linear mixed models to determine factors significantly associatedwith outcomes. Of 186 horses presented with SI, 161/186 (86.6{\%}) were treated and145/161 (90.1{\%}) survived to discharge. The majority of joints were treated with synoviallavage (93.8{\%}). One hundred and twenty horses were included in the return to functionanalysis and 79 (65{\%}) returned to function. Increasing number of days of treatmentwith systemic antimicrobials was associated with increased likelihood of survival foreach horse (OR 1.15, 95{\%} CI 1.04−1.27, P = 0.025) and when considering eachindividual synovial structure (OR 1.11, 95{\%} CI 1.04−1.17, P = 0.004). Horses treatedwith doxycycline were less likely to return to function (OR 0.39, 95{\%} CI 0.19−0.8, P =0.031). The overall rate of survival of horses treated with SI is good. The likelihood ofreturn to function is lower than for survival. The findings of this study, combined withrelevant antimicrobial stewardship practices, can be used as a part of evidence-baseddecision-making when veterinarians are treating horses with SI.",
author = "Dani Crosby and Raphael Labens and Kris Hughes and Sharon Nielson and Bryan Hilbert",
year = "2019",
month = "10",
day = "22",
doi = "10.3389/fvets.2019.00367",
language = "English",
volume = "6",
pages = "1--9",
journal = "Frontiers in Veterinary Science",
issn = "2297-1769",
publisher = "Frontiers Media",

}

Factors associated with survival and return to function following synovial infections in horses. / Crosby, Dani; Labens, Raphael; Hughes, Kris; Nielson, Sharon; Hilbert, Bryan.

In: Frontiers in Veterinary Science, Vol. 6, 367, 22.10.2019, p. 1-9.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Factors associated with survival and return to function following synovial infections in horses

AU - Crosby, Dani

AU - Labens, Raphael

AU - Hughes, Kris

AU - Nielson, Sharon

AU - Hilbert, Bryan

PY - 2019/10/22

Y1 - 2019/10/22

N2 - Synovial infections (SI) are common in horses of all ages and can be associated withhigh rates of morbidity and mortality. Identifying factors influencing survival and returnto function may be useful for management of affected individuals and determinationof prognosis. The objectives of this study were to identify factors associated withsurvival and return to function of horses and foals with SI presented to an equinehospital. This study is a retrospective case series. Data were collected from medicalrecords of all horses with SI that were presented to a single equine hospital betweenApril 1st, 2008 and May 1st, 2017. Long–term follow up was obtained by a semistructured telephone questionnaire of clinical outcomes and analysis of online racerecords. Univariate models were created using generalized linear and linear mixed modelsto assess factors associated with outcomes. Multivariable models were created usinggeneralized linear and linear mixed models to determine factors significantly associatedwith outcomes. Of 186 horses presented with SI, 161/186 (86.6%) were treated and145/161 (90.1%) survived to discharge. The majority of joints were treated with synoviallavage (93.8%). One hundred and twenty horses were included in the return to functionanalysis and 79 (65%) returned to function. Increasing number of days of treatmentwith systemic antimicrobials was associated with increased likelihood of survival foreach horse (OR 1.15, 95% CI 1.04−1.27, P = 0.025) and when considering eachindividual synovial structure (OR 1.11, 95% CI 1.04−1.17, P = 0.004). Horses treatedwith doxycycline were less likely to return to function (OR 0.39, 95% CI 0.19−0.8, P =0.031). The overall rate of survival of horses treated with SI is good. The likelihood ofreturn to function is lower than for survival. The findings of this study, combined withrelevant antimicrobial stewardship practices, can be used as a part of evidence-baseddecision-making when veterinarians are treating horses with SI.

AB - Synovial infections (SI) are common in horses of all ages and can be associated withhigh rates of morbidity and mortality. Identifying factors influencing survival and returnto function may be useful for management of affected individuals and determinationof prognosis. The objectives of this study were to identify factors associated withsurvival and return to function of horses and foals with SI presented to an equinehospital. This study is a retrospective case series. Data were collected from medicalrecords of all horses with SI that were presented to a single equine hospital betweenApril 1st, 2008 and May 1st, 2017. Long–term follow up was obtained by a semistructured telephone questionnaire of clinical outcomes and analysis of online racerecords. Univariate models were created using generalized linear and linear mixed modelsto assess factors associated with outcomes. Multivariable models were created usinggeneralized linear and linear mixed models to determine factors significantly associatedwith outcomes. Of 186 horses presented with SI, 161/186 (86.6%) were treated and145/161 (90.1%) survived to discharge. The majority of joints were treated with synoviallavage (93.8%). One hundred and twenty horses were included in the return to functionanalysis and 79 (65%) returned to function. Increasing number of days of treatmentwith systemic antimicrobials was associated with increased likelihood of survival foreach horse (OR 1.15, 95% CI 1.04−1.27, P = 0.025) and when considering eachindividual synovial structure (OR 1.11, 95% CI 1.04−1.17, P = 0.004). Horses treatedwith doxycycline were less likely to return to function (OR 0.39, 95% CI 0.19−0.8, P =0.031). The overall rate of survival of horses treated with SI is good. The likelihood ofreturn to function is lower than for survival. The findings of this study, combined withrelevant antimicrobial stewardship practices, can be used as a part of evidence-baseddecision-making when veterinarians are treating horses with SI.

U2 - 10.3389/fvets.2019.00367

DO - 10.3389/fvets.2019.00367

M3 - Article

C2 - 31696123

VL - 6

SP - 1

EP - 9

JO - Frontiers in Veterinary Science

JF - Frontiers in Veterinary Science

SN - 2297-1769

M1 - 367

ER -