Feasibility of molecularly targeted therapy for tooth regeneration

Katsu Takahashi, Honoka Kiso, Kazuyuki Saito, Yumiko Togo, Hiroko Tsukamoto, Boyen Huang, Kazuhisa Bessho

Research output: Book chapter/Published conference paperChapter (peer-reviewed)peer-review

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The tooth is a complex organ that consists of enamel, dentin, cementum, and pulp. Missing teeth is frequently occurring problem in aging populations. To treat these defects, the current approach involves prostheses, autotransplantation, and dental implants. The exploration of new strategies for tooth replacement has become a hot topic. Using the foundations of experimental embryology, developmental and molecular biology, tooth regeneration is becoming realistic possibility. Several different methods have been proposed to achieve biological tooth replacement. These include scaffold-based tooth regeneration, cell pellet engineering, stimulation of the formation of a third dentition, and gene-manipulated tooth regeneration. The idea that a third dentition might be locally induced to replace missing teeth is an attractive concept (Young et al., 2005; Edward & Mason, 2006; Takahashi et al., 2008,2013). This approach is generally presented in terms of adding molecules to induce de novo tooth initiation in the mouth. Tooth development is the result of reciprocal and reiterative signaling between oral ectoderm-derived dental epithelium and cranial neural crest cellderived dental mesenchyme under genetic control.
Original languageEnglish
Title of host publicationNew trends in tissue engineering and regenerative medicine
Subtitle of host publicationOfficial book of the Japanese society for regenerative medicine
EditorsHideharu Hibi, Minoru Ueda
Place of PublicationCroatia
Number of pages12
ISBN (Print)9789535117247
Publication statusPublished - 2014


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