Femtomolar detection of a cancer biomarker protein in serum with ultralow background current by anodic stripping voltammetry

Muhammad J.A. Shiddiky, Prakash H. Kithva, Sakandar Rauf, Matt Trau

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

An electrochemical immunosensor for the detection of a cancer biomarker protein in serum at femtomolar concentrations with ultralow background response has been developed, which consists of (i) a hydrophilic polyacrylic acid brush-modified indium tin oxide substrate as an antifouling substrate and (ii) a graphene–quantum dots–antibody ‘bionanoconjugate’ as a signal amplification label in voltammetric detection of targets in a glassy carbon electrode.

Original languageEnglish
Pages (from-to)6411-6413
Number of pages3
JournalChemical Communications
Volume48
Issue number51
DOIs
Publication statusPublished - 30 May 2012

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