TY - JOUR
T1 - Fractal, multifractal, and lacunarity analysis of microglia in tissue engineering
AU - Karperien, Audrey L.
AU - Jelinek, Herbert F.
N1 - Includes bibliographical references.
PY - 2015
Y1 - 2015
N2 - Tissue engineering is currently one of the most exciting fields in biology (Grayson et al., 2009). Fractal analysis is equally exciting (Di Ieva et al., 2013), as is the study of microglia, the brain's immuno-inflammatory cell, recently shown to be of considerably more importance than previously imagined in both healthy and diseased brain (Tremblay et al., 2011). Each of these fields is developing at a pace far outstripping our capacity to integrate and translate the information gained into clinical use (Karperien et al., 2008b, 2013; Jelinek et al., 2011, 2013), and the excitement more than trebles where these fields intersect. Three elements of fractal analysis ' monofractal, multifractal, and lacunarity analysis ' applied to microglia may contribute significantly to the next steps forward in engineered tissues and 3D models in neuroscience.
AB - Tissue engineering is currently one of the most exciting fields in biology (Grayson et al., 2009). Fractal analysis is equally exciting (Di Ieva et al., 2013), as is the study of microglia, the brain's immuno-inflammatory cell, recently shown to be of considerably more importance than previously imagined in both healthy and diseased brain (Tremblay et al., 2011). Each of these fields is developing at a pace far outstripping our capacity to integrate and translate the information gained into clinical use (Karperien et al., 2008b, 2013; Jelinek et al., 2011, 2013), and the excitement more than trebles where these fields intersect. Three elements of fractal analysis ' monofractal, multifractal, and lacunarity analysis ' applied to microglia may contribute significantly to the next steps forward in engineered tissues and 3D models in neuroscience.
KW - Open access version available
KW - Fractal analysis
KW - Lacunarity
KW - Microglia
KW - Multifractal
KW - Tissue engineering
U2 - 10.3389/fbioe.2015.00051
DO - 10.3389/fbioe.2015.00051
M3 - Article
C2 - 25927064
VL - 3
SP - 1
EP - 4
JO - Frontiers in Bioengineering and Biotechnology
JF - Frontiers in Bioengineering and Biotechnology
SN - 2296-4185
M1 - 51
ER -