Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids

Xu Si, Wenting Shang, Zhongkai Zhou, Guanghou Shui, Sin Man Lam, Chris Blanchard, Padraig Strappe

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

In this study, gamma-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet. ERB-containing diet stimulated butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp., and associated synthesizing enzymes. This altered short-chain fatty acid (SCFA) distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by downregulating orexigenic factors. Together with the enhanced fatty acid β-oxidation highlighted by Prkaa2, Ppara, and Scd1 expression via AMPK signaling pathway and nonalcoholic fatty liver disease pathway, energy expenditure was positively modulated. Serum lipid compositions showed ERB supplement exhibited a more efficient effect on lowering serum sphingolipids, which was closely associated with the status of insulin resistance. Consistently, genes of Ppp2r3b and Prkcg, involved in the function of ceramides in blocking insulin action, were also downregulated following ERB intervention. Enriched GABA and phenolic acids were supposed to be responsible for the health-beneficial effects.

Original languageEnglish
Pages (from-to)881-890
Number of pages10
JournalJournal of Agricultural and Food Chemistry
Volume66
Issue number4
DOIs
Publication statusPublished - 31 Jan 2018

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Volatile Fatty Acids
rice bran
gamma-aminobutyric acid
short chain fatty acids
Nutrition
intestinal microorganisms
insulin resistance
energy expenditure
gamma-Aminobutyric Acid
Energy Metabolism
Insulin Resistance
Insulin
Diet
Sphingolipids
AMP-Activated Protein Kinases
Glucagon-Like Peptide 1
Butyrates
Ceramides
Propionates
Leptin

Cite this

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title = "Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids",
abstract = "In this study, gamma-aminobutyric acid (GABA) enriched rice bran (ERB) was supplemented to obese rats to investigate the attenuation of metabolic syndromes induced by high-fat diet. ERB-containing diet stimulated butyrate and propionate production by promoting Anaerostipes, Anaerostipes sp., and associated synthesizing enzymes. This altered short-chain fatty acid (SCFA) distribution further enhanced circulatory levels of leptin and glucagon-like peptide-1, controlling food intake by downregulating orexigenic factors. Together with the enhanced fatty acid β-oxidation highlighted by Prkaa2, Ppara, and Scd1 expression via AMPK signaling pathway and nonalcoholic fatty liver disease pathway, energy expenditure was positively modulated. Serum lipid compositions showed ERB supplement exhibited a more efficient effect on lowering serum sphingolipids, which was closely associated with the status of insulin resistance. Consistently, genes of Ppp2r3b and Prkcg, involved in the function of ceramides in blocking insulin action, were also downregulated following ERB intervention. Enriched GABA and phenolic acids were supposed to be responsible for the health-beneficial effects.",
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Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids. / Si, Xu; Shang, Wenting; Zhou, Zhongkai; Shui, Guanghou; Lam, Sin Man; Blanchard, Chris; Strappe, Padraig.

In: Journal of Agricultural and Food Chemistry, Vol. 66, No. 4, 31.01.2018, p. 881-890.

Research output: Contribution to journalArticle

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AU - Shang, Wenting

AU - Zhou, Zhongkai

AU - Shui, Guanghou

AU - Lam, Sin Man

AU - Blanchard, Chris

AU - Strappe, Padraig

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