Gated myocardial perfusion SPECT: 180 degrees versus 360 degrees reconstruction

Introduction: The impact of 180 degrees myocardial perfusion SPECT reconstruction on decreasing resolution may also impact on LV volume and LVEF. The purpose of this project was to determine the relationship between 180 degrees and 360 degrees gated myocardial perfusion SPECT reconstruction for the LV volumes and LVEF determined by QGS analysis and to determine whether QGS software is robust to variations in reconstruction parameters. Methodology: Each of 50 gated SPECT data sets (25 rest and 25 stress) were reconstructed using both 180 degrees and 360 degrees filtered backprojection simultaneously and quantified with automated QGS software to determine the LVEF, end diastolic volume (EDV) and end systolic volume (ESV). Results: The mean LVEF for 180 degrees reconstruction was 49.5% and 49.7% for 360 degrees reconstruction. No statistically significant difference was noted between matched pairs (P = 0.51). The mean EDV for 180 degrees reconstruction was 108.3 ml and 104.6 ml for 360 degrees reconstruction. A statistically significant difference was noted between matched pairs (P = 0.0006). The mean ESV for 180 degrees reconstruction was 58.9 ml and 56.7 ml for 360 degrees reconstruction. Again a statistically significant difference was noted between matched pairs (P = 0.0031). Conclusion: The QGS determined LVEF is robust to variations in reconstruction strategy. If 360 degrees data is acquired, QGS software is capable of performing reliable reconstruction.