Generation of Articular Cartilage Specific Chondrocytes Through Gene Modification of Dedifferentiated Chondrocytes and Adipose Derived Stem Cells by Lentiviral Vector Expression of Defined Factors

Research output: ThesisDoctoral Thesis

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Abstract

Our aim was to investigate the re-differentiation capacity of canine and equine chondrocytes following lentiviral vector mediated expression of induced pluripotent stem (iPS) cell factors Oct4, Sox2, Klf4 and c-Myc (OSKM) along with the chondrogenic transcription factor Sox9. We hypothesised that lentiviral expression of the iPS factors and Sox9 enhance chondrogenesis. Lentiviral vector expression was efficient at transgene delivery in these cell types.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Charles Sturt University
Supervisors/Advisors
  • Strappe, Padraig, Principal Supervisor
Award date01 Aug 2015
Place of PublicationAustralia
Publisher
Publication statusPublished - 2015

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