Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthropathy. Inflammation in AS is poorly understood. TBX21 encodes T-bet, a transcription factor, lying within a locus with genome-wide significant association with AS. T-bet is implicated in innate and adaptive immunity. However, the role of T-bet in AS pathogenesis is unclear.
Lau, M. C., Keith, P., Costello, M-E., Bradbury, L. A., Hollis, K. A., Thomas, R., Thomas, G. P., Brown, M. A., & Kenna, T. J. (2017). Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis. Annals of the Rheumatic Diseases, 76(1), 261-269. https://doi.org/10.1136/annrheumdis-2015-208677