Genetic association of ankylosing spondylitis with TBX21 influences T-bet and pro-inflammatory cytokine expression in humans and SKG mice as a model of spondyloarthritis

Max C Lau, Patricia Keith, Mary-Ellen Costello, Linda A Bradbury, Kelly A Hollis, Ranjeny Thomas, Gethin P Thomas, Matthew A Brown, Tony J Kenna

    Research output: Contribution to journalArticle

    15 Citations (Scopus)

    Abstract

    Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthropathy. Inflammation in AS is poorly understood. TBX21 encodes T-bet, a transcription factor, lying within a locus with genome-wide significant association with AS. T-bet is implicated in innate and adaptive immunity. However, the role of T-bet in AS pathogenesis is unclear.
    Original languageEnglish
    Pages (from-to)261-269
    Number of pages9
    JournalAnnals of the Rheumatic Diseases
    Volume76
    Issue number1
    Early online dateDec 2016
    DOIs
    Publication statusPublished - Jan 2017

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