Genetics of diabetic kidney disease: A follow‐up study in the Arab population of the United Arab Emirates

Wael M. Osman, Herbert Jelinek, Guan K. Tay, Mohamed H. Hassan, Wael Almahmeed, Ahsan H. Khandoker, Kinda Khalaf, Habiba S Alsafar

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Two genome‐wide association studies in European and Japanese populations reported on new loci for diabetic kidney disease (DKD), including FTO. In this study, we have replicated these investigations on a cohort of 410 Type 2 diabetes mellitus (T2DM) patients of Arab origin from the United Arab Emirates (UAE).
The cohort included 145 diabetic patients diagnosed with DKD and 265 diabetics free of the disease. In general, we were able to confirm the association between the FTO locus and DKD, as reported in the Japanese population. Specifically, there were significant associations with two single nucleotide polymorphisms (SNPs), namely rs1421086 (p = .013, OR = 1.52 depending on allele G, 95% CI: 1.09–2.11) and rs17817449 (p = .0088, OR = 1.55 depending on allele C, 95% CI: 1.12–2.14) of the FTO locus. Both SNPs were in linkage disequilibrium with rs56094641, also as reported in the Japanese population. While the alleles of both SNPs, which increase the risk of DKD, were associated with higher Body Mass Index (BMI), their associations with DKD were independent of the BMI effects.
This study confirms that FTO is a multiethnic locus for DKD which is independent from any influence of BMI and/or obesity.
Original languageEnglish
Article numbere985
Pages (from-to)1-5
Number of pages5
JournalMolecular Genetics and Genomic Medicine
Volume7
Issue number12
Early online date30 Sep 2019
DOIs
Publication statusPublished - Dec 2019

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