Genetics of diabetic kidney disease: A follow‐up study in the Arab population of the United Arab Emirates

Wael M. Osman; Herbert Jelinek; Guan K. Tay; Mohamed H. Hassan; Wael Almahmeed; Ahsan H. Khandoker; Kinda Khalaf; Habiba S Alsafar

doi:10.1002/mgg3.985

Genetics of diabetic kidney disease: A follow‐up study in the Arab population of the United Arab Emirates

Wael M. Osman, Herbert Jelinek, Guan K. Tay, Mohamed H. Hassan, Wael Almahmeed, Ahsan H. Khandoker, Kinda Khalaf, Habiba S Alsafar

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Abstract

Background

Two genome-wide association studies in European and Japanese populations reported on new loci for diabetic kidney disease (DKD), including FTO. In this study, we have replicated these investigations on a cohort of 410 Type 2 diabetes mellitus (T2DM) patients of Arab origin from the United Arab Emirates (UAE).

Methods and Results

The cohort included 145 diabetic patients diagnosed with DKD and 265 diabetics free of the disease. In general, we were able to confirm the association between the FTO locus and DKD, as reported in the Japanese population. Specifically, there were significant associations with two single nucleotide polymorphisms (SNPs), namely rs1421086 (p = .013, OR = 1.52 depending on allele G, 95% CI: 1.09–2.11) and rs17817449 (p = .0088, OR = 1.55 depending on allele C, 95% CI: 1.12–2.14) of the FTO locus. Both SNPs were in linkage disequilibrium with rs56094641, also as reported in the Japanese population. While the alleles of both SNPs, which increase the risk of DKD, were associated with higher Body Mass Index (BMI), their associations with DKD were independent of the BMI effects.

Conclusions

This study confirms that FTO is a multiethnic locus for DKD which is independent from any influence of BMI and/or obesity.

Original language	English
Article number	e985
Pages (from-to)	1-5
Number of pages	5
Journal	Molecular Genetics and Genomic Medicine
Volume	7
Issue number	12
Early online date	30 Sept 2019
DOIs	https://doi.org/10.1002/mgg3.985
Publication status	Published - Dec 2019

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@article{b0b709c21a934d39821cbd0d16dfdb3d,

title = "Genetics of diabetic kidney disease: A follow‐up study in the Arab population of the United Arab Emirates",

abstract = " Background Two genome-wide association studies in European and Japanese populations reported on new loci for diabetic kidney disease (DKD), including FTO. In this study, we have replicated these investigations on a cohort of 410 Type 2 diabetes mellitus (T2DM) patients of Arab origin from the United Arab Emirates (UAE). Methods and Results The cohort included 145 diabetic patients diagnosed with DKD and 265 diabetics free of the disease. In general, we were able to confirm the association between the FTO locus and DKD, as reported in the Japanese population. Specifically, there were significant associations with two single nucleotide polymorphisms (SNPs), namely rs1421086 (p = .013, OR = 1.52 depending on allele G, 95% CI: 1.09–2.11) and rs17817449 (p = .0088, OR = 1.55 depending on allele C, 95% CI: 1.12–2.14) of the FTO locus. Both SNPs were in linkage disequilibrium with rs56094641, also as reported in the Japanese population. While the alleles of both SNPs, which increase the risk of DKD, were associated with higher Body Mass Index (BMI), their associations with DKD were independent of the BMI effects. Conclusions This study confirms that FTO is a multiethnic locus for DKD which is independent from any influence of BMI and/or obesity. ",

author = "Osman, {Wael M.} and Herbert Jelinek and Tay, {Guan K.} and Hassan, {Mohamed H.} and Wael Almahmeed and Khandoker, {Ahsan H.} and Kinda Khalaf and Alsafar, {Habiba S}",

year = "2019",

month = dec,

doi = "10.1002/mgg3.985",

language = "English",

volume = "7",

pages = "1--5",

journal = "Molecular Genetics and Genomic Medicine",

issn = "2324-9269",

publisher = "John Wiley & Sons",

number = "12",

}

TY - JOUR

T1 - Genetics of diabetic kidney disease

T2 - A follow‐up study in the Arab population of the United Arab Emirates

AU - Osman, Wael M.

AU - Jelinek, Herbert

AU - Tay, Guan K.

AU - Hassan, Mohamed H.

AU - Almahmeed, Wael

AU - Khandoker, Ahsan H.

AU - Khalaf, Kinda

AU - Alsafar, Habiba S

PY - 2019/12

Y1 - 2019/12

N2 - Background Two genome-wide association studies in European and Japanese populations reported on new loci for diabetic kidney disease (DKD), including FTO. In this study, we have replicated these investigations on a cohort of 410 Type 2 diabetes mellitus (T2DM) patients of Arab origin from the United Arab Emirates (UAE). Methods and Results The cohort included 145 diabetic patients diagnosed with DKD and 265 diabetics free of the disease. In general, we were able to confirm the association between the FTO locus and DKD, as reported in the Japanese population. Specifically, there were significant associations with two single nucleotide polymorphisms (SNPs), namely rs1421086 (p = .013, OR = 1.52 depending on allele G, 95% CI: 1.09–2.11) and rs17817449 (p = .0088, OR = 1.55 depending on allele C, 95% CI: 1.12–2.14) of the FTO locus. Both SNPs were in linkage disequilibrium with rs56094641, also as reported in the Japanese population. While the alleles of both SNPs, which increase the risk of DKD, were associated with higher Body Mass Index (BMI), their associations with DKD were independent of the BMI effects. Conclusions This study confirms that FTO is a multiethnic locus for DKD which is independent from any influence of BMI and/or obesity.

AB - Background Two genome-wide association studies in European and Japanese populations reported on new loci for diabetic kidney disease (DKD), including FTO. In this study, we have replicated these investigations on a cohort of 410 Type 2 diabetes mellitus (T2DM) patients of Arab origin from the United Arab Emirates (UAE). Methods and Results The cohort included 145 diabetic patients diagnosed with DKD and 265 diabetics free of the disease. In general, we were able to confirm the association between the FTO locus and DKD, as reported in the Japanese population. Specifically, there were significant associations with two single nucleotide polymorphisms (SNPs), namely rs1421086 (p = .013, OR = 1.52 depending on allele G, 95% CI: 1.09–2.11) and rs17817449 (p = .0088, OR = 1.55 depending on allele C, 95% CI: 1.12–2.14) of the FTO locus. Both SNPs were in linkage disequilibrium with rs56094641, also as reported in the Japanese population. While the alleles of both SNPs, which increase the risk of DKD, were associated with higher Body Mass Index (BMI), their associations with DKD were independent of the BMI effects. Conclusions This study confirms that FTO is a multiethnic locus for DKD which is independent from any influence of BMI and/or obesity.

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DO - 10.1002/mgg3.985

M3 - Article

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JO - Molecular Genetics and Genomic Medicine

JF - Molecular Genetics and Genomic Medicine

IS - 12

M1 - e985

ER -

Genetics of diabetic kidney disease: A follow‐up study in the Arab population of the United Arab Emirates

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