Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity

Sameer Dinkar Pant, Peter Karlskov-Mortensen, Susanna Cirera Salicio, Lisette J. A. Kogelman, Mette Juul Jacobsen, Camilla Vibeke Sichlau Bruun, Claus Bøttcher Jørgensen, Theo H. E. Meuwissen, Haja N Kadarmideen, Merete Fredholm

Research output: Book chapter/Published conference paperConference paper

Abstract

Purebred Duroc and Yorkshire sows were crossed with Göttingen minipig boars to obtain two separate F2 intercross resource populations (n=287 and 279 respectively). Several obesity, metabolic and slaughter measurements were recorded from birth to slaughter (220±45 days). In addition, body composition was determined at about two months of age (64±11 days) via dual-energy x-ray absorptiometry (DXA) scanning. All pigs were genotyped using Illumina Porcine 60k SNP Beadchip and a combined LDLA approach was used to perform genome-wide linkage and association analysis for body fat traits. Subsequently bioinformatic analysis was performed to identify genes in close proximity of chromosomal positions where statistically significant QTLs were identified. Several important genes previously linked to obesity (e.g. BBS4, CHRNA2, DLK1), along with other novel genes were identified, that together provide novel insights that may further the current understanding of the molecular mechanisms underlying human obesity.
Original languageEnglish
Title of host publicationProceedings, 10th World Congress of Genetics Applied to Livestock Production
Pages1-4
Number of pages4
Publication statusPublished - 2014
Event10th World Congress of Genetics Applied to Livestock Production: WCGALP 2014 - Westin Bayshore Conference Center, Vancouver, Canada
Duration: 17 Aug 201422 Aug 2014
https://web.archive.org/web/20140805071635/http://www.wcgalp.com/ (Conference website)
http://www.wcgalp.org/proceedings/2014 (Conference proceedings)

Conference

Conference10th World Congress of Genetics Applied to Livestock Production
CountryCanada
CityVancouver
Period17/08/1422/08/14
OtherThe joint US-Canada organizing committee is proud to welcome you to the 10th World Congress on Genetics Applied to Livestock Production (WCGALP) being held from 17 – 22 August 2014 at the Westin Bayshore Conference Center situated on the bay in the gorgeous city of Vancouver, British Columbia, Canada.

This congress is the premier conference for researchers and professionals involved in genetic improvement of livestock. Delegates from around the world gather every four years to attend the scientific program and network with colleagues. This 10th WGCALP builds from previous successful congresses in Madrid (1974 and 1982), Lincoln (USA, 1986), Edinburgh (UK, 1990), Guelph (Canada, 1994), Armidale (Australia, 1998), Montpellier (France, 2002), Belo Horizonte (Brazil, 2006) and Leipzig (Germany, 2010).
Internet address

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Linkage Disequilibrium
Adipose Tissue
Swine
Obesity
Genome
Genes
Miniature Swine
Genome-Wide Association Study
Body Composition
Computational Biology
Single Nucleotide Polymorphism
X-Rays
Parturition
Population

Cite this

Pant, S. D., Karlskov-Mortensen, P., Salicio, S. C., Kogelman, L. J. A., Jacobsen, M. J., Bruun, C. V. S., ... Fredholm, M. (2014). Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity. In Proceedings, 10th World Congress of Genetics Applied to Livestock Production (pp. 1-4)
Pant, Sameer Dinkar ; Karlskov-Mortensen, Peter ; Salicio, Susanna Cirera ; Kogelman, Lisette J. A. ; Jacobsen, Mette Juul ; Bruun, Camilla Vibeke Sichlau ; Jørgensen, Claus Bøttcher ; Meuwissen, Theo H. E. ; Kadarmideen, Haja N ; Fredholm, Merete. / Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity. Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. pp. 1-4
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title = "Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity",
abstract = "Purebred Duroc and Yorkshire sows were crossed with G{\"o}ttingen minipig boars to obtain two separate F2 intercross resource populations (n=287 and 279 respectively). Several obesity, metabolic and slaughter measurements were recorded from birth to slaughter (220±45 days). In addition, body composition was determined at about two months of age (64±11 days) via dual-energy x-ray absorptiometry (DXA) scanning. All pigs were genotyped using Illumina Porcine 60k SNP Beadchip and a combined LDLA approach was used to perform genome-wide linkage and association analysis for body fat traits. Subsequently bioinformatic analysis was performed to identify genes in close proximity of chromosomal positions where statistically significant QTLs were identified. Several important genes previously linked to obesity (e.g. BBS4, CHRNA2, DLK1), along with other novel genes were identified, that together provide novel insights that may further the current understanding of the molecular mechanisms underlying human obesity.",
keywords = "LDLA, Pig model, Genomics, QTL mapping",
author = "Pant, {Sameer Dinkar} and Peter Karlskov-Mortensen and Salicio, {Susanna Cirera} and Kogelman, {Lisette J. A.} and Jacobsen, {Mette Juul} and Bruun, {Camilla Vibeke Sichlau} and J{\o}rgensen, {Claus B{\o}ttcher} and Meuwissen, {Theo H. E.} and Kadarmideen, {Haja N} and Merete Fredholm",
year = "2014",
language = "English",
pages = "1--4",
booktitle = "Proceedings, 10th World Congress of Genetics Applied to Livestock Production",

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Pant, SD, Karlskov-Mortensen, P, Salicio, SC, Kogelman, LJA, Jacobsen, MJ, Bruun, CVS, Jørgensen, CB, Meuwissen, THE, Kadarmideen, HN & Fredholm, M 2014, Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity. in Proceedings, 10th World Congress of Genetics Applied to Livestock Production. pp. 1-4, 10th World Congress of Genetics Applied to Livestock Production, Vancouver, Canada, 17/08/14.

Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity. / Pant, Sameer Dinkar; Karlskov-Mortensen, Peter; Salicio, Susanna Cirera; Kogelman, Lisette J. A.; Jacobsen, Mette Juul; Bruun, Camilla Vibeke Sichlau; Jørgensen, Claus Bøttcher; Meuwissen, Theo H. E.; Kadarmideen, Haja N; Fredholm, Merete.

Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. p. 1-4.

Research output: Book chapter/Published conference paperConference paper

TY - GEN

T1 - Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity

AU - Pant, Sameer Dinkar

AU - Karlskov-Mortensen, Peter

AU - Salicio, Susanna Cirera

AU - Kogelman, Lisette J. A.

AU - Jacobsen, Mette Juul

AU - Bruun, Camilla Vibeke Sichlau

AU - Jørgensen, Claus Bøttcher

AU - Meuwissen, Theo H. E.

AU - Kadarmideen, Haja N

AU - Fredholm, Merete

PY - 2014

Y1 - 2014

N2 - Purebred Duroc and Yorkshire sows were crossed with Göttingen minipig boars to obtain two separate F2 intercross resource populations (n=287 and 279 respectively). Several obesity, metabolic and slaughter measurements were recorded from birth to slaughter (220±45 days). In addition, body composition was determined at about two months of age (64±11 days) via dual-energy x-ray absorptiometry (DXA) scanning. All pigs were genotyped using Illumina Porcine 60k SNP Beadchip and a combined LDLA approach was used to perform genome-wide linkage and association analysis for body fat traits. Subsequently bioinformatic analysis was performed to identify genes in close proximity of chromosomal positions where statistically significant QTLs were identified. Several important genes previously linked to obesity (e.g. BBS4, CHRNA2, DLK1), along with other novel genes were identified, that together provide novel insights that may further the current understanding of the molecular mechanisms underlying human obesity.

AB - Purebred Duroc and Yorkshire sows were crossed with Göttingen minipig boars to obtain two separate F2 intercross resource populations (n=287 and 279 respectively). Several obesity, metabolic and slaughter measurements were recorded from birth to slaughter (220±45 days). In addition, body composition was determined at about two months of age (64±11 days) via dual-energy x-ray absorptiometry (DXA) scanning. All pigs were genotyped using Illumina Porcine 60k SNP Beadchip and a combined LDLA approach was used to perform genome-wide linkage and association analysis for body fat traits. Subsequently bioinformatic analysis was performed to identify genes in close proximity of chromosomal positions where statistically significant QTLs were identified. Several important genes previously linked to obesity (e.g. BBS4, CHRNA2, DLK1), along with other novel genes were identified, that together provide novel insights that may further the current understanding of the molecular mechanisms underlying human obesity.

KW - LDLA

KW - Pig model

KW - Genomics

KW - QTL mapping

UR - http://www.wcgalp.org/proceedings/2014

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UR - https://web.archive.org/web/20140123040251/http://www.wcgalp.com:80/call-for-papers

UR - https://asas.confex.com/asas/WCGALP14/webprogram/Paper8938.html

M3 - Conference paper

SP - 1

EP - 4

BT - Proceedings, 10th World Congress of Genetics Applied to Livestock Production

ER -

Pant SD, Karlskov-Mortensen P, Salicio SC, Kogelman LJA, Jacobsen MJ, Bruun CVS et al. Genome-wide linkage disequilibrium linkage analysis (LDLA) of body fat traits in an F2 porcine model for human obesity. In Proceedings, 10th World Congress of Genetics Applied to Livestock Production. 2014. p. 1-4