Genomic characterisation of Torque teno virus in pigeon highlights cryptic host divergence in old world pigeon from Australasia

Research output: Other contribution to conferencePosterpeer-review

Abstract

Torque teno virus (TTV) is a non-enveloped single-stranded, negative sense DNA virus and a major component of non-pathogenic virobiota of humans, non-human primates, and some farm animals. In recent years, pigeon associated TTV (PTTV) has been identified and genetically characterised in different parts of the world, although the breadth of genetic diversity, epidemiology or phylogenetic structure of PTTV is yet to be explored. We tested 139 pigeons from 22 endemic Columbid species from Australia, Papua New Guinea and New Zealand and identified PTTV with very high frequency (98%). Downstream phylogenetic analyses using complete genome as well putative capsid protein sequences unveiled several well supported lineage that vastly expanded the known diversity in PTTV and provided evidence for deep host codivergence. The population genetic structure of PTTV lacked significant spatiotemporal signal but demonstrated cryptic gene flow among different host adapted clusters highlighting frequent host-switching events. Our calibrated tree topology shows major divergences in PTTV amongst old world pigeon that coincided with palaeobiological events of Papuan uplift in the Early- to Mid-Miocene era.
Original languageEnglish
Publication statusPublished - 2024
EventThe Australian Society for Microbiology (ASM) Annual Scientific Meeting 2024 - Brisbane Convention & Exhibition Centre, Brisbane, Australia
Duration: 01 Jul 202404 Jul 2024
https://asmicro-2024.p.asnevents.com.au/

Conference

ConferenceThe Australian Society for Microbiology (ASM) Annual Scientific Meeting 2024
Country/TerritoryAustralia
CityBrisbane
Period01/07/2404/07/24
Internet address

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