Glanzmann thrombasthenia: an update

Massimo Franchini, Emmanuel J Favaloro, Giuseppe Lippi

Research output: Contribution to journalReview articlepeer-review

37 Citations (Scopus)

Abstract

Glanzmann thrombasthenia (GT) is a rare autosomal recessive disorder characterized by qualitative or quantitative abnormalities of the platelet membrane glycoprotein (GP) IIb/IIIa. Physiologically, this platelet receptor normally binds several adhesive plasma proteins, and this facilitates attachment and aggregation of platelets to ensure thrombus formation at sites of vascular injury. The lack of resultant platelet aggregation in GT leads to mucocutaneous bleeding whose manifestation may be clinically variable, ranging from easy bruising to severe and potentially life-threatening hemorrhages. In this review we discuss the main characteristics of GT, focusing on molecular defects, diagnostic evaluation and treatment strategies.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalClinica Chimica Acta
Volume411
Issue number1-2
DOIs
Publication statusPublished - Jan 2010

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